Observation on application effect of dexmedetomidine sedative anesthesia in emergency tibial and fibular fracture surgery
Objective To analyze the safety of dexmedetomidine sedative anesthesia in emergency tibial and fibular fracture surgery.Methods 70 patients undergoing emergency tibial and fibular fracture surgery were randomly divided into an observation group and a control group,with 35 patients in each group.The observation group received intravenous sedative anesthesia with dexmedetomidine,and the control group received epidural anesthesia with sufentanil.Comparison was made on the visual analogue scale(VAS)score at different time points(immediately,30 min,1 h,2 h,3 h,6 h,12 h,24 h,36 h,and 48 h after surgery)and different states(at rest and during activity),sedation scores at 5 min after extubation,cough score at extubation,and adverse reactions between the two groups.Results In the observation group,the VAS scores at 30 min,1 h,2 h,3 h,6 h,12 h,24 h,36 h,and 48 h after surgery,at rest and during activity were(5.26±1.12),(5.00±0.73),(5.49±1.15),(5.74±1.52),(7.26±0.85),(5.23±0.84),(4.29±0.83),(4.00±0.73),(2.51±0.51),(2.23±0.43),(2.77±0.84)points,which were lower than(6.71±1.32),(6.29±0.83),(5.97±0.71),(6.46±0.85),(8.03±0.71),(6.49±0.51),(4.80±1.08),(4.51±0.51),(3.26±0.44),(3.03±0.71),(3.54±1.12)points in the control group,and the difference was statistically significant(P<0.05).The sedation score at 5 min after extubation in the observation group was(4.29±0.75)points and the cough score at extubation was(2.37±0.97)points,which were lower than(4.91±0.70)and(2.83±0.79)points in the control group,and the difference was statistically significant(P<0.05).The incidence rates of nausea,vomiting,itching and respiratory depression in the observation group were 2.5%,5.0%,7.5%and 5.0%,which were lower than 37.5%,40.0%,30.0%and 40.0%in the control group,and the difference was statistically significant(P<0.05).Conclusion Dexmedetomidine is highly safe and has less adverse reactions for emergency tibial and fibula fracture surgery,which is worthy of clinical recommendation.
DexmedetomidineSedative anesthesiaTibial and fibular fracture surgerySufentanil
万方数据
维普
