Clinical study of preemptive analgesia with parecoxib sodium before anesthesia induction in percutaneous foraminoscopic surgery for lumbar disc herniation
Objective To explore th e clinical effect of preemptive analgesia with parecoxib sodium before anesthesia induction in percutaneous foraminoscopic surgery for lumbar disc herniation.Methods 70 patients with lumbar disc herniation who underwent percutaneous foraminoscopic surgery were included in the study,and the selected patients were randomly divided into an observation group and a control group,with 35 cases in each group.The control group was given conventional anesthesia and analgesia,and the observation group was given preemptive analgesia with parecoxib sodium.Both groups were compared in terms of hemodynamic indexes[heart rate(HR),mean arterial pressure(MAP)]at different times[during skin cutting(T1),separation of muscle and ligament(T2),stimulation of nerve roots(T3),and suturing(T4)],visual analogue scale(VAS)score at different time(2,6,12,24 h postoperatively)and incidence of postoperative adverse reactions after surgery.Results HR and MAP levels at T2,T3 and T4 were lower than those that T1;at T1,T2,T3 and T4,HR levels were(79.63±8.26),(75.68±7.55),(72.17±6.49)and(70.04±5.07)beats/min in the observation group,which were lower than(84.15±8.49),(80.31±7.44),(78.65±6.58)and(75.41±6.19)beats/min in the control group;MAP levels were(85.44±10.43),(77.33±10.12),(78.65±9.88)and(79.86±9.53)mm Hg(1 mm Hg=0.133 kPa)in the observation group,which were higher than(79.22±10.66),(71.51±10.39),(73.21±8.57)and(74.57±8.46)mm Hg in the control group(P<0.05).The VAS scores of the observation group at 2,6,12 and 24 h postoperatively were(2.26±0.46),(2.86±0.68),(3.16±0.77)and(3.79±0.94)points,which were lower than(2.79±0.58),(3.46±0.79),(3.76±0.91)and(4.27±0.89)points of the control group(P<0.05).The incidence of postoperative adverse reactions in the observation group(20.00%)was higher than that in the control group(11.43%),but the difference was not statistically significant(P>0.05).Conclusion Preemptive analgesia with parecoxib sodium in patients with lumbar disc herniation can improve intraoperative hemodynamics and effectively reduce postoperative pain before anesthesia induction in percutaneous foraminoscopic surgery.This program is safe and conducive to prognosis and rehabilitation.
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