Clinical observation of sodium hyaluronate combined with nonsteroidal anti-inflammatory drug in the treatment of knee osteoarthritis
Objective To investigate the therapeutic effect of sodium hyaluronate + Nonsteroidal anti-inflammatory drug on knee osteoarthritis(KOA).Methods 200 patients with KOA were randomly divided into the observation group and the control group,each with 100 cases.The observation was treated with sodium hyaluronate + nonsteroidal anti-inflammatory drug,and the control group was treated with sodium hyaluronate.Both groups were compared in terms of inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP)]levels,Western Ontario and McMaster University(WOMAC),knee joint function score(Lysholm score),knee injury and osteoarthritis outcome score(KOOS score).Results After treatment,the observation group had TNF-α of(6.1±0.7)pg/ml,IL-6 of(2.2±0.2)ng/L and CRP of(10.3±3.0)mg/L,which were lower than(7.3±1.0)pg/ml,(3.1±0.8)ng/L and(13.0±3.2)mg/L in the control group(P<0.05).After treatment,the scores of pain,stiffness and joint function in the observation group were(15.3±1.7),(5.5±0.7)and(36.7±5.6)points,which were lower than(21.3±2.1),(8.0±1.0)and(60.3±7.8)points in the control group(P<0.05).After treatment,the scores of lameness,stair climbing,squatting,use of support,pain,instability,interlocking and swelling in the observation group were(4.5±0.6),(9.2±1.0),(4.4±0.4),(4.3±0.4),(24.6±3.2),(24.0±2.8),(7.6±1.1)and(9.1±0.9)points,which were higher than(3.1±0.4),(7.2±0.8),(3.1±0.3),(3.1±0.3),(20.6±2.8),(20.7±2.6),(3.3±1.5)and(7.6±0.8)points in the control group(P<0.05).After treatment,the scores of knee joint related quality of life,exercise and recreation capacity,activities of daily living,symptoms,and pain in the observation group were(10.8±1.8),(12.6±2.9),(55.9±3.7),(20.8±3.5)and(23.4±2.1)points,which were higher than(8.8±1.6),(9.7±2.4),(49.2±4.5),(15.1±3.2)and(19.5±2.7)points in the control group(P<0.05).Conclusion Sodium hyaluronate combined with nonsteroidal anti-inflammatory drug can effectively improve the knee joint function of patients with KOA,with high value.
万方数据
维普
