Clinical observation of modified Tongqiao Huoxue Decoction combined with mannitol in the treatment of vertebral-artery-type cervical spondylosis
Objective To explore the clinical efficacy of modified Tongqiao Huoxue Decoction combined with mannitol in the treatment of vertebral-artery-type cervical spondylosis.Methods 50 patients with vertebral-artery-type cervical spondylosis were randomly divided into a control group and an observation group,with 25 cases in each group.The control group was treated with mannitol injection and flunarizine capsule,and the observation group was treated with modified Tongqiao Huoxue Decoction on the basis of the control group.Both groups were compared in terms of treatment effect,the scores of symptoms and signs,and the level of vertebral artery blood flow indexes[mean blood flow velocity in the left vertebral artery(LVA-Vm),mean blood flow velocity in the right vertebral artery(RVA-Vm),resistance index in the left vertebral artery(LVA-RI),resistance index in the right vertebral artery(LVA-RI)]before and after treatment,and safety.Results The total effective rate of treatment in the observation group was 96.00%,which was higher than 76.00%in the control group(P<0.05).After treatment,the scores of symptoms and signs in both groups were higher than those before treatment;and the score of symptoms and signs of(21.06±2.12)points in the observation group was higher than(13.47±1.95)points in the control group(P<0.05).After treatment,the levels of LVA-Vm and LVA-VM in both groups were higher than those before treatment,and the levels of LVA-RI and LVA-RI were lower than those before treatment;LVA-Vm of(31.20±3.32)cm/s and LVA-VM of(32.06±2.97)cm/s in the observation group were higher than(27.65±2.87)and(28.11±2.44)cm/s in the control group;LVA-RI of(0.54±0.06)and LVA-RI of(0.46±0.10)in the observation group were lower than(0.62±0.07)and(0.64±0.09)in the control group(P<0.05).There were no three major routine abnormalities or abnormal liver and kidney function in the two groups during treatment,and no other adverse reactions,indicating good safety.Conclusion Modified Tongqiao Huoxue Decoction combined with mannitol is effective in the treatment of vertebral-artery-type cervical spondylosis,which can effectively improve the blood flow status of the vertebral artery in patients with high safety.
万方数据
维普
