Study on effect of cefiderocol on metallo-β-lactamase-producing gram-negative bacteria
metallo-β-lactamase(MBLs)-producing gram-negative bacteria are common pathogens of clinical infection,which can cause a variety of serious infections,among which metallo-β-lactamase-producing Klebsiella pneumoniae(KP)is an important hospital-acquired infection in the world,posing a serious threat to the current anti-infective treatment.As a new cephalosporin,cefiderocol has the characteristics of strong antibacterial activity,wide range of action,strong tissue penetration,etc.It has strong antibacterial activity against carbapenemases-producing enterobacter,Acinetobacter baumannii,pseudomonas aeruginosa,stenomonas maltophilia,and it also has quite good activity against metallo-β-lactamase.In this study,the effect of cefiderocol on metallo-β-lactamase producing gram-negative bacteria is analyzed comprehensively.
CefiderocolMetallo-β-lactamase-producing gram-negative bacteriaDrug resistanceClinical effectResearch status
万方数据
维普
