Effect of labetalol combined with nifedipine in the treatment of pregnancy-induced hypertension
Objective To observe the clinical effect of labetalol combined with nifedipine in the treatment of pregnancy-induced hypertension.Methods 78 patients with pregnancy-induced hypertension were randomly divided into a control group and an observation group,with 39 cases in each group.The control group was treated with labetalol,and the observation group was treated with labetalol and nifedipine.Patients in both groups were compared in terms of neonatal adverse outcomes,adverse pregnancy outcomes,adverse drug reactions,clinical efficacy,hemorheology(whole blood low shear viscosity,whole blood high shear viscosity,plasma viscosity),blood pressure[systolic blood pressure(SBP),diastolic blood pressure(DBP)]and 24-h urinary protein quantity.Results The incidence of neonatal adverse outcomes in the observation group was 7.69%,which was lower than 25.64%in the control group(P<0.05).The incidence of adverse pregnancy outcomes in the observation group was 10.26%,which was lower than 28.21%in the control group(P<0.05).After treatment,the observation group had SBP of(120.56±6.65)mm Hg(1 mm Hg=0.133 kPa),DBP of(86.25±6.52)mm Hg,and 24-h urinary protein quantity of(1.04±0.32)g/24 h,which were lower than(132.45±9.23)mm Hg,(98.45±7.12)mm Hg,and(1.63±0.39)g/24 h in the control group(P<0.05).The incidence of adverse drug reactions of 5.13%in the observation group was lower than 23.08%in the control group(P<0.05).In the observation group,the whole blood high shear viscosity was(3.05±0.26)mPa·s,the whole blood low shear viscosity was(11.10±1.25)mPa·s and the plasma viscosity was(1.32±0.12)mPa·s,which were lower than(4.99±0.44),(14.87±2.05)and(1.88±0.21)mPa·s in the control group(P<0.05).In the observation group,the physiologic function score was(22.59±1.32)points,the psychological function score was(23.65±2.64)points,the physical function score was(22.46±1.45)points and the social function score was(22.63±1.45)points,which were higher than(17.56±1.41),(18.45±3.52),(15.96±1.52)and(17.52±1.36)points in the control group(P<0.05).The total effective rate of 94.87%in the observation group was higher than 79.49%in the control group(P<0.05).Conclusion The combination of labetalol and nifedipine is highly effective in the treatment of pregnancy induced hypertension and is recommended for clinical use.
万方数据
维普
