Effects of Ganoderma Tiaozhi Tea on metabolic indicators and renin angiotensin aldosterone system in hypertension and hyperlipidemia
Objective To observe the effect of Ganoderma Tiaozhi Tea on metabolic indicators and renin-angiotensin-aldosterone system(RAAS)in hypertension and hyperlipidemia.Methods 101 patients with hypertension and hyperlipidemia were selected as the research subjects.They were divided into a treatment group(57 cases)and a control group(54 cases)according to the random numerical table.Both groups were instructed to live a healthy lifestyle.The control group was treated with oral amlodipine besylate and rosuvastatin,and the treatment group was treated with Ganoderma Tiaozhi Tea on the basis of the control group.Both groups were compared in terms of fasting plasma glucose(FPG),lipid lipids[total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)],uric acid(UA),fasting insulin(FINS),insulin resistance index(HOMA-IR),RAAS[plasma rennin activity(PRA)],Angiotensin Ⅱ(Ang Ⅱ),aldosterone(ALD)]before and after treatment.Results After treatment,the levels of TC,TG and LDL-C in both groups decreased more significantly compared with those before treatment,and the level of HDL-C increased;the levels of FPG and UA in the treatment group decreased more significantly compared with those before treatment.The difference was statistically significant(P<0.05).The levels of FPG and UA in the control group after treatment were not statistically significant compared with those before treatment(P>0.05).Compared with the control group,the levels of TC,TG and LDL-C in the treatment group decreased more significantly after treatment,and the level of HDL-C increased more significantly.The difference was statistically significant(P<0.05).After treatment,there was no significant difference in FPG and UA between the two groups(P>0.05).After treatment,FINS and HOMA-IR in both groups decreased compared with those before treatment,and the difference was statistically significant(P<0.05).After treatment,the treatment group had FINS of(89.51±33.00)pmol/L and HOMA-IR of(3.16±1.44),which were lower than(104.09±38.76)pmol/L and(3.81±1.67)in the control group,and the difference was statistically significant(P<0.05).After treatment,PRA,Ang Ⅱ and ALD in the treatment group decreased more significantly compared with those before treatment,and the difference was statistically significant(P<0.05).There was no significant difference in PRA in the control group before and after treatment(P>0.05).After treatment,Ang Ⅱ and ALD in the control group decreased more significantly compared with those before treatment,and the difference was statistically significant(P<0.05).After treatment,the treatment group had PRA of(1.61±0.74)ng/(ml·h),Ang Ⅱ of(87.19±10.05)pg/ml and ALD of(112.08±30.85)pg/ml,which were lower than(2.02±0.32)ng/(ml·h),(93.08±14.80)pg/ml and(128.25±25.25)pg/ml in the control group.The difference was statistically significant(P<0.05).No serious adverse reactions occurred in both groups during treatment.Conclusion Ganoderma Tiaozhi Tea has a definite therapeutic effect on hypertension combined with hyperlipidemia.It can effectively control blood lipids,improve HOMA-IR,regulate the RAAS system,and has good safety.It is a worthwhile traditional Chinese medicine preparation.
HypertensionHyperlipidemiaGanoderma Tiaozhi TeaMetabolic disordersRenin-angiotensin-aldosterone system
万方数据
维普
