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枣仁安神胶囊联合酒石酸唑吡坦治疗失眠的临床疗效

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目的 分析失眠患者使用枣仁安神胶囊联合酒石酸唑吡坦片进行治疗的效果。方法 88 例失眠患者作为研究对象,经随机抽样法分为常规组和研究组,每组 44 例。常规组患者使用酒石酸唑吡坦片治疗,研究组使用枣仁安神胶囊联合酒石酸唑吡坦片治疗。比较两组治疗效果、不良情绪评分、睡眠质量评分、中医证候积分、心理健康状况评分。结果 常规组治疗总有效率为 81。82%,研究组治疗总有效率为 97。73%;和常规组相比,研究组治疗总有效率更高(P<0。05)。治疗前,两组焦虑、抑郁评分相比无明显差异(P>0。05);常规组治疗后焦虑、抑郁评分分别为(53。73±3。31)、(51。88±2。95)分,研究组治疗后焦虑、抑郁评分分别为(42。03±1。46)、(45。15±0。68)分,治疗后,研究组焦虑、抑郁评分均低于常规组,组间具有明显差异(P<0。05)。治疗前,两组主观睡眠质量、白天功能障碍、睡眠时间、入睡时间、多梦、夜间觉醒评分相比无明显差异(P>0。05);治疗后,常规组主观睡眠质量、白天功能障碍、睡眠时间、入睡时间、多梦、夜间觉醒评分分别为(1。68±0。57)、(1。12±0。28)、(1。22±0。11)、(1。38±0。54)、(1。33±1。21)、(1。45±0。52)分,研究组分别为(1。12±0。24)、(0。75±0。24)、(0。98±0。27)、(0。51±0。16)、(0。61±0。04)、(0。94±0。41)分,研究组主观睡眠质量、白天功能障碍、睡眠时间、入睡时间、多梦、夜间觉醒评分均低于常规组(P<0。05)。治疗前,两组中医证候积分、心理健康状况评分相比无明显差异(P>0。05);治疗后,研究组中医证候积分、心理健康状况评分分别为(0。51±0。44)、(138。67±16。14)分,常规组分别为(1。39±0。47)、(165。54±14。58)分,研究组均低于常规组(P<0。05)。结论 失眠患者使用枣仁安神胶囊联合酒石酸唑吡坦片进行治疗,可以改善患者睡眠质量,减少患者不良情绪,和单用酒石酸唑吡坦片相比,疗效更高,临床应用价值较高。
Clinical efficacy of Zaoren Anshen capsule combined with zolpidem tartrate on insomnia patients
Objective To analyze the effect of Zaoren Anshen capsule combined with zolpidem tartrate on insomnia patients.Methods A total of 88 patients with insomnia were studied and randomly divided into the conventional group and the study group,with 44 cases in each group.The conventional group was treated with zolpidem tartrate tablets,while the study group was treated with Zaoren Anshen capsule and zolpidem tartrate tablets.The therapeutic effect,negative emotion score,sleep quality score,traditional Chinese medicine syndrome score and mental health score were compared between the two groups.Results The total effective rate was 81.82%in the conventional group and 97.73%in the study group.Compared with the conventional group,the total effective rate of the study group was higher(P<0.05).Before treatment,there were no significant differences in scores of anxiety and depression between the two groups(P>0.05).After treatment,the scores of anxiety and depression were(53.73±3.31)and(51.88±2.95)points in the conventional group,and(42.03±1.46)and(45.15±0.68)points in the study group,respectively.After treatment,the scores of anxiety and depression in the study group were lower than those in the conventional group,and there were significant differences between the groups(P<0.05).Before treatment,there were no significant differences in scores of subjective sleep quality,daytime dysfunction,sleep time,sleep latency,dreaminess and night wakening between the two groups(P>0.05).After treatment,the scores of subjective sleep quality,daytime dysfunction,sleep time,sleep latency,dreaminess and night awakening in the conventional group were(1.68±0.57),(1.12±0.28),(1.22±0.11),(1.38±0.54),(1.33±1.21)and(1.45±0.52)points,and those of the study group were(1.12±0.24),(0.75±0.24),(0.98±0.27),(0.51±0.16),(0.61±0.04)and(0.94±0.41)points.The scores of subjective sleep quality,daytime dysfunction,sleep time,sleep latency,dreaminess and night awakening in the study group were lower than those in the conventional group(P<0.05).Before treatment,there were no significant differences in traditional Chinese medicine syndrome score and mental health score between the two groups(P>0.05).After treatment,the traditional Chinese medicine syndrome score and mental health score in the study group were(0.51±0.44)and(138.67±16.14)points,and those in the conventional group were(1.39±0.47)and(165.54±14.58)points.The study group was lower than the conventional group(P<0.05).Conclusion Zaoren Anshen capsule combined with zolpidem tartrate for insomnia patients can improve the sleep quality,reduce the negative mood of patients.Compared with zolpidem tartrate tablets alone,the efficacy is higher,and the clinical application value is higher.

Zaoren Anshen capsuleZolpidem tartrateInsomniaEfficacy

荣小荣、王慧、刁婷婷

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252000 聊城市第四人民医院药学部

枣仁安神胶囊 酒石酸唑吡坦 失眠 疗效

2024

中国现代药物应用
中国水利电力医学科学技术学会

中国现代药物应用

影响因子:0.862
ISSN:1673-9523
年,卷(期):2024.18(5)
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