Efficacy observation of acupoint moxibustion combined with fluoxetine in treating post-stroke depression of liver depression and spleen deficiency type
Objective To explore the efficacy of acupuncture moxibustion and fluoxetine in treating post-stroke depression of liver depression and spleen deficiency type.Methods 80 patients with post-stroke depression of liver depression and spleen deficiency type were selected and randomly divided into a study group and a control group,with 40 cases in each group.Patients in the control group were treated with oral fluoxetine,and patients in the study group were treated with acupuncture moxibustion on the basis of the control group.Patients in both groups were compared in terms of neurotransmitter[brain-derived neurotrophic factor(BDNF),norepinephrine(NE),5-hydroxytryptamine(5-HT)]level,National Institutes of Health Stroke Scale(NIHSS)score,Hamilton Depression Scale(HAMD)score,therapeutic efficacy and the incidence of adverse reactions.Results In the study group,the brain-derived neurotrophic factor was(42.69±1.64)ng/ml,the norepinephrine was(10.29±1.26)μg/L,and the 5-hydroxytryptamine was(140.25±2.61)ng/ml.In the control group,the brain-derived neurotrophic factor was(36.51±2.61)ng/ml,the norepinephrine was(8.13±1.27)μg/L,and the 5-hydroxytryptamine was(111.81±3.52)ng/ml.The levels of brain-derived neurotrophic factor,norepinephrine and 5-hydroxytryptamine in the study group were higher than those in the control group,and the difference was statistically significant(P<0.05).NIHSS score of(2.89±1.02)points in the study group was significantly lower than(4.26±1.21)points in the control group,and the difference was statistically significant(P<0.05).HAMD score of(8.24±1.02)points in the study group was significantly lower than(13.26±1.62)points in the control group,and the difference was statistically significant(P<0.05).The total effective rate of the study group was 95.00%,which was significantly higher than 80.00%of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group was 7.50%,which was significantly lower than 27.50%in the control group,and the difference was statistically significant(P<0.05).Conclusion For patients with post-stroke depression of liver depression and spleen deficiency type,acupuncture moxibustion combined with fluoxetine has a better effect,which can effectively reduce the rate of complications,and is worth widely used in clinical practice.
Acupoint moxibustionFluoxetinePost-stroke depressionLiver depression and spleen deficiency type
万方数据
维普
