Study on correlation of polymorphism of CYP3A7 and MDR1 genes with analgesic effect
Objective To analyze the correlation of polymorphism of CYP3A7 and MDR1 genes and analgesic effect.Methods The general clinical data of 87 patients undergoing abdominal surgery were retrospectively analyzed.Sufentanil was used for postoperative analgesia,and the related factors affecting the postoperative analgesia effect of patients were analyzed.Results Among the 87 patients who underwent abdominal surgery,there were 45 cases of mild postoperative pain(mild pain group)and 42 cases of moderate to severe postoperative pain(moderate to severe pain group).There was no significant difference in age,gender,American Society of Anesthesiologists(ASA)grade and CYP3A7 gene polymorphism between the mild pain group and the moderate to severe pain group(P>0.05).The difference between the two groups was statistically significant when comparing the polymorphisms of the MDR1 2677G>T/A gene(P<0.05).The statistically significant single factors of patients in the mild pain group and the moderate to severe pain group were included in the Logistic regression model for multifactorial analysis,and the results showed that MDR1 2677G>T/A GG,GA,TA,and AA were the factors affecting postoperative analgesic effect(OR=0.998,1.078,1.044,1.038;P<0.05).Conclusion MDR1 gene polymorphism may affect the postoperative analgesic effect of patients,and the relevant factors such as patient genotype should be comprehensively considered in the formulation of clinical analgesic treatment plan.
万方数据
维普
