Effects of diabetes mellitus on pulmonary function and blood gas analysis in patients with chronic obstructive pulmonary disease
Objective To explore the effects of diabetes mellitus(DM)on pulmonary function and blood gas analysis in patients with chronic obstructive pulmonary disease(COPD).Methods 30 patients with simple COPD were selected as group A,and concurrent 30 COPD patients with course of diabetes less than 10 years were selected as group B,and 30 COPD patients with course of diabetes more than 10 years were selected as group C.The pulmonary function and blood gas analysis indicators of all patients were monitored.Comparison was made on blood gas analysis indicators[arterial partial pressure of carbon dioxide(PaCO2)and arterial partial pressure of oxygen(PaO2)],pulmonary function indicators[forced expiratory volume in one second(FEV1)as a percentage to the predicted value,FEV1/forced vital capacity(FVC),mid-expiratory flow(FEF25%-75%),forced vital capacity(FVC)as a percentage to the predicted value,diffusing lung capacity of carbon monoxide/alveolar volume(DLCO/VA),diffusing lung capacity of carbon monoxide(DLCO)]among the three groups.Results There was no significant difference in PaCO2 between every two groups(P>0.05).The PaO2 in group B and group C were(63.29±5.18)and(51.18±11.15)mm Hg(1 mm Hg= 0.133 kPa),which was lower than(68.43±10.32)mm Hg in group A,and the PAO2 in group C was lower than that in group B(P<0.05).There were no significant differences in FEV1 as a percentage to the predicted value,FEV1/FVC,and FEF25%-75%between every two groups(P>0.05).The FVC as a percentage to the predicted value in group A,group B and group C were(76.32±9.34)%,(69.14±8.23)%and(61.35±10.78)%,respectively.The DLCO/VA of group A,group B and group C were(3.56±0.89),(3.12±0.73)and(2.51±0.67)ml/(mm Hg·min·L),respectively.The DLCO of group A,group B and group C were(18.41±2.69),(17.76±1.87)and(16.34±1.23)ml/(mm Hg·min),respectively.There were significant differences in FVC as a percentage to the predicted value and DLCO/VA between every two groups(P<0.05).There was no significant difference in DLCO between group A and group B(P<0.05).The DLCO of group C was lower than that of group A and group B(P<0.05).Conclusion The diffusion function and lung function of diabetes mellitus patients with course of diabetes more than 10 years are getting lower and lower,and targeted treatment should be taken according to the actual situation of patients'blood gas index and pulmonary function,so as to effectively improve their body function and promote the improvement of patients'quality of life.
Chronic obstructive pulmonary diseaseDiabetes mellitusPulmonary functionBlood gas analysis
万方数据
维普
