Study on value of high-frequency ultrasound-guided coarse needle biopsy and tumor marker detection in differential diagnosis of benign and malignant breast masses
Objective To explore the value of high-frequency ultrasound-guided coarse needle biopsy and tumor marker detection in differential diagnosis of benign and malignant breast masses.Methods 140 patients with breast mass were selected as the study objects,72 cases of breast cancer and 68 cases of benign breast lesions were confirmed by postoperative pathological examination.All patients underwent high-frequency ultrasound examination,high-frequency ultrasound-guided coarse needle biopsy and tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199),carbohydrate antigen 125(CA125)]detection before surgery.The diagnostic efficacy of different examination methods(high-frequency ultrasound and high-frequency ultrasound-guided coarse needle biopsy)for breast cancer was compared,as well as the levels of tumor markers(CEA,CA199,CA125)in patients with breast cancer and benign breast lesions,and the ultrasound performance characteristics and tumor marker levels in patients with different high-frequency ultrasound-guided coarse needle biopsy results.Results High-frequency ultrasound-guided coarse needle biopsy misdiagnosed 4 cases of breast cancer as benign breast lesions,1 case of breast fibroma and 2 cases of fibroid cyst as breast cancer.The sensitivity,specificity and accuracy of high-frequency ultrasound-guided coarse needle biopsy in the diagnosis of breast cancer were 94.44%,95.59%and 95.00%,which were significantly higher than 68.06%,79.41%and 73.57%of high-frequency ultrasound(P<0.05).CEA,CA199 and CA125 levels in breast cancer patients were(4.55±1.22)ng/ml,(31.86±9.56)U/ml and(26.12±6.18)U/ml,which were significantly higher than(1.68±0.52)ng/ml,(12.10±4.33)U/ml and(11.54±4.83)U/ml in patients with benign breast lesions(P<0.05).The differences in ultrasound characteristics such as maximum diameter of the mass,morphology,borders,internal echoes,lymph node enlargement,calcification,and blood flow signals were statistically significant when comparing benign and malignant patients undergoing high-frequency ultrasound-guided coarser needle biopsy(P<0.05).The CEA,CA199,and CA125 levels in benign patients undergoing high-frequency ultrasound-guided coarse needle biopsy were(1.74±0.55)ng/ml,(12.43±4.40)U/ml,and(11.62±4.88)U/ml,which were lower than(4.53±1.26)ng/ml,(31.88±9.68)U/ml,and(26.25±6.20)U/ml in malignant patients(P<0.05).Conclusion High-frequency ultrasound-guided coarse needle biopsy can better differentiate breast cancer from benign breast lesions,and its diagnostic efficiency is significantly better than that of high-frequency ultrasound alone,and the results of the aspiration biopsy have a clear correlation with the tumor markers and ultrasound characteristics,which can provide a basis for guiding the treatment of breast mass.
Ultrasound-guided coarse needle biopsyBreast massesBreast cancerBenign breast lesionsTumor markers
万方数据
维普
