Evaluation of the clinical effect of propofol combined with remifentanil in anesthesia in elderly patients with hypertension
Objective To explore the clinical effect of propofol combined with remifentanil in anesthesia in elderly patients with hypertension.Methods 126 elderly hypertensive patients were randomly divided into the study group and the control group,with 63 cases in each group.The control group was anesthetised with propofol,and the study group was anesthetised with propofol combined with remifentanil.Patients in both group were compared in terms of anesthetic effects(propofol dosage,time to loss of consciousness,recovery time,occurrence of adverse reactions,recovery time of orientation),visual analogue scale(VAS)score and Ramsay score before and after treatment,hemodynamic parameters[heart rate(HR),mean arterial pressure(MAP),systolic blood pressure(SBP)and diastolic blood pressure(DBP)]at different time points.Results The propofol dosage of(88.26±23.37)mg in the study group was lower than(109.08±23.74)mg in the control group;in the study group,the time to loss of consciousness was(30.26±9.37)s,the recovery time was(287.51±18.93)s,and the recovery time of orientation was(341.17±10.97)s,which were shorter than(37.08±10.74),(335.65±19.28)and(441.45±15.84)s in the control group;the incidence of adverse reactions of 3.2%in the study group was lower than 12.7%in the control group(P<0.05).After anesthesia,VAS score of(1.22±0.13)points in the study group was lower than(3.11±0.12)points in the control group,and Ramsay score of(4.21±0.45)points was higher than(2.37±0.54)points in the control group(P<0.05).Immediately after intubation(T1),immediately at the beginning of surgery(T2),and at the end of surgery(T3),HR,MAP,SBP,DBP of the study group were lower than those of the control group(P<0.05).Conclusion The application of propofol combined with remifentanil in elderly patients with hypertension has more significant anesthetic effect and longer analgesia time,which can reduce the postoperative stress reaction and adverse reaction probability of patients,improve the hemodynamic level and make patients wake up as soon as possible,which is worthy of promotion.
PropofolRemifentanilCombined anesthesiaHypertension in the elderlySurgical anesthesiaClinical effect
万方数据
维普
