Clinical efficacy of amlodipine combined with atorvastatin calcium tablets in the treatment of hypertension complicated with coronary heart disease
Objective To analyze the active effect of amlodipine combined with atorvastatin calcium tablets in the treatment of patients with hypertension and coronary heart disease.Methods 78 patients with hypertension and coronary heart disease were divided into a control group and an observation group by random number table method,with 39 cases in each group.The control group was treated with amlodipine,and the observation group was treated with amlodipine and atorvastatin calcium tablets.The blood pressure,blood lipids,clinical effect,incidence of complications,self-care ability[self-care ability scale(ESCA)score]and quality of life(QOL)score of the two groups were compared.Results After treatment,the systolic blood pressure and diastolic blood pressure in both groups were lower than those before treatment;the systolic blood pressure of(122.23±10.74)mm Hg(1 mm Hg= 0.133 kPa)and diastolic blood pressure of(87.58±9.86)mm Hg in the observation group were lower than(137.69±12.56)and(95.86±8.05)mm Hg in the control group;the difference was significant(P<0.05).The observation group had total cholesterol of(3.06±0.36)mmol/L,low density lipoprotein cholesterol of(1.51±0.21)mmol/L,triglyceride of(1.54±0.14)mmol/L,which were lower than(4.14±0.74),(1.87±0.16),(2.03±0.06)mmol/L in the control group;the high density lipoprotein cholesterol of(1.54±0.14)mmol/L in the observation group was higher than(1.25±0.13)mmol/L in the control group;the difference was significant(P<0.05).The total effective rate of 94.87%in the observation group was significantly higher than 74.36%in the control group(P<0.05).The incidence of adverse reactions in the observation group was 7.69%,which was significantly lower than 28.21%in the control group(P<0.05).After treatment,ESCA score of(123.45±12.63)points and QOL score of(57.56±6.13)points in the observation group were higher than(108.23±10.65)and(48.52±6.22)points in the control group,and the difference was significant(P<0.05).Conclusion Amlodipine combined with atorvastatin calcium tablets has achieved good therapeutic effects in the treatment of hypertension combined with coronary heart disease.