Effect analysis of Canesten in the treatment of candida vaginitis during pregnancy and its influence on inflammatory factors and symptom improvement time
Objective To study the effect of clotrimazole vaginal tablets(trade name:Canesten)in the treatment of candida vaginitis during pregnancy and its influence on inflammatory factors and symptom improvement time.Methods 60 pregnant women with candidal vaginitis were selected as the subjects of this study.They were divided into the observation group(30 cases,treated with Canesten)and the control group(30 cases,treated with nystatin vaginal suppository)by numerical table method.Both groups were compared in terms of therapeutic effect,incidence of adverse reactions,time to symptom improvement,results of vaginal bacterial culture before and after treatment,levels of inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and interleukin-8(IL-8)].Results The total effective rate of clinical treatment in the observation group was 96.7%(29/30),which was significantly higher than 73.3%(22/30)in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 3.3%(1/30),which was lower than 23.3%(7/30)in the control group,and the difference was statistically significant(P<0.05).The symptom improvement time was(10.33±2.25)d in the observation group and(18.99±3.52)d in the control group.The time to symptom improvement of the observation group was significantly shorter than that of the control group(P<0.05).After treatment,the viable count of lactobacillus,enterobacter and yeast in both groups were better than those before treatment;the viable count of lactobacillus,enterobacter and yeast in the observation group were better than those before treatment;the difference was statistically significant(P<0.05).After treatment,there were no significant differences in viable count of staphylococcus within and between the two groups(P>0.05).After treatment,the observation group had CRP of(3.15±0.51)mg/L,IL-6 of(69.87±4.67)pg/ml,TNF-α of(3.41±0.20)μg/L and IL-8 of(1.99±0.40)pg/ml,which were lower than(5.30±0.63)mg/L,(81.92±5.05)pg/ml,(4.87±0.38)μg/L and(3.19±0.51)pg/ml in the control group.The difference was statistically significant(P<0.05).There were significant differences in CRP,IL-6,TNF-α and IL-8 between the two groups before and after treatment(P<0.05).Conclusion The treatment of pregnant women with candidal vaginitis by Canesten can effectively improve the clinical efficacy,promote the improvement of inflammatory factors and symptoms,and has higher safety,which is worthy of promotion.
万方数据
维普
