Study on the distribution of traditional Chinese medicine syndrome types in middle-aged and elderly people with primary osteoporosis and its correlation with bone metabolic markers
Objective To explore the distribution of traditional Chinese medicine syndrome types in primary osteoporosis,and its correlation with bone metabolic markers{parathyroid hormone(PTH),N-terminal mid-fragment(N-MID),25-hydroxyvitamin D[25-(OH)D3],β-Crosslaps}.Methods The clinical data of 165 middle-aged and elderly patients with primary osteoporosis were retrospectively analyzed.The age distribution and distribution of traditional Chinese medicine syndrome types were compared among patients of different genders,as well as the bone mineral density(T value)and bone metabolic markers[25-(OH)D3,N-MID,PTH,β-Crosslaps]of patients with different traditional Chinese medicine syndrome types.Results There was no significant difference in age distribution between male and female patients(P>0.05).In male patients,the proportion of traditional Chinese medicine syndrome types from high to low was kidney Yang deficiency syndrome(42.6%)>blood stasis Qi stagnation syndrome(23.4%)>liver and kidney Yin deficiency syndrome(21.3%)>spleen and kidney Yang deficiency syndrome(12.8%).In female patients,the proportion of traditional Chinese medicine syndrome types from high to low was liver and kidney Yin deficiency syndrome(44.9%)>spleen and kidney Yang deficiency syndrome(22.9%)>kidney Yang deficiency syndrome(19.5%)>blood stasis and Qi stagnation syndrome(12.7%).There were significant differences between male patients and female patients in distribution of traditional Chinese medicine syndrome types(P<0.05).T values of patients with syndromes of kidney Yang deficiency,liver and kidney Yin deficiency,spleen and kidney Yang deficiency and blood stasis Qi stagnation were(-3.02±0.48),(-2.9±0.47),(-3.30±0.74)and(-2.72±0.18),and 25-(OH)D3 were(7.97±3.37),(21.86±6.94),(14.70±6.47)and(15.45±5.55)ng/ml,respectively.T value and 25-(OH)D3 level of patients with different traditional Chinese medicine syndrome types had statistical significance(P<0.05).There were no significant differences in N-MID,β-Crosslaps and PTH levels among patients with different traditional Chinese medicine syndrome types(P>0.05).Conclusion Primary osteoporosis in middle-aged and elderly people has a different distribution of traditional Chinese medicine syndrome types in men and women.T value and 25-(OH)D3 can be useful in determining and identifying traditional Chinese medicine syndromes of primary osteoporosis in middle-aged and elderly people.
Middle-aged and elderlyPrimary osteoporosisBone mineral densityTraditional Chinese medicine syndrome typesGenderBone metabolism
万方数据
维普
