Observation of the effect of misoprostol combined with magnesium sulfate on postpartum hemorrhage and blood pressure of patients with pregnancy-induced hypertension syndrome
Objective To study the effect of misoprostol combined with magnesium sulfate on postpartum hemorrhage and blood pressure of patients with pregnancy-induced hypertension syndrome.Methods A total of 66 women with pregnancy-induced hypertension syndrome were randomly divided into a control group and an observation group,with 33 cases in each group.The control group was treated with magnesium sulfate,while the observation group was treated with misoprostol combined with magnesium sulfate.The postpartum hemorrhage,blood pressure,coagulation function,stress response,and incidence of adverse pregnancy outcomes were compared between the two groups.Results The bleeding volume of the observation group were(198.31±15.20)and(296.09±16.12)ml at 2 and 24 h postpartum,which were lower than the control group's(289.09±17.73)and(403.07±18.02)ml(P<0.05).Compared with before treatment,the diastolic blood pressure,systolic blood pressure and mean arterial pressure of the two groups decreased after treatment,and the difference was statistically significant(P<0.05).But there was no significant difference in diastolic blood pressure,systolic blood pressure and mean arterial pressure between the two groups after treatment(P>0.05).Compared with before treatment,the fibrinogen decreased in both groups after treatment,and thrombin time and activated partial thromboplastin time prolonged in both groups;after treatment,the observation group had higher fibrinogen of(3.96±0.72)g/L than(3.26±0.88)g/L in the control group;the observation group had prothrombin time of(10.93±1.26)s and activated partial thromboplastin time of(31.28±2.09)s,which were shorter than(12.35±1.81)and(35.18±2.87)s in the control group(P<0.05).Compared with before treatment,both groups showed a decrease in malondialdehyde(MDA)and an increase in superoxide dismutase(SOD)after treatment;the observation group had lower MDA of(12.90±1.59)nmol/ml after treatment than(17.86±2.15)nmol/ml in the control group,and higher SOD of(123.78±12.96)U/ml than(90.45±9.68)U/ml in the control group(P<0.05).The incidence of adverse pregnancy outcome of 9.09%in the observation group was lower than 30.30%in the control group(P<0.05).Conclusion The combination of misoprostol and magnesium sulfate can effectively reduce blood pressure levels,postpartum hemorrhage,and the incidence of adverse pregnancy outcome in patients with pregnancy-induced hypertension syndrome,and has practical significance for promotion.
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