The effect of saxagliptin combined with metformin on blood glucose control rate in patients with type 2 diabetes mellitus
Objective To explore the effectiveness of saxagliptin combined with metformin on blood glucose control rate in patients with type 2 diabetes mellitus.Methods 113 patients with type 2 diabetes mellitus were divided into a control group(56 cases)and an observation group(57 cases)by envelope method.The control group was treated with oral metformin,while the observation group was treated with saxagliptin on the basis of the control group.The glucose metabolism,islet function,body micro inflammatory status,blood lipid,and quality of life were compared between the two groups before and after treatment.Results After treatment,the observation group had mean blood glucose of(7.82±0.56)mmol/L,standard deviation of blood glucose of(1.59±0.12)mmol/L,and mean blood glucose fluctuation of(3.12±0.28)mmol/L,which were lower than(9.95±1.03),(2.03±0.21)and(5.20±0.17)mmol/L in the control group;the observation group had higher blood glucose control rate of 78.95%than 55.36%in the control group(P<0.05).After treatment,the observation group had fasting insulin of(17.16±1.25)mU/L and insulin resistance index of(5.86±0.37),which were lower than(19.39±1.01)mU/L and(7.90±0.58)in the control group(P<0.05).After treatment,the observation group had C-reactive protein(CRP)of(6.72±1.19)mg/L,interleukin-6(IL-6)of(9.61±1.53)pg/ml,and interleukin-1β(IL-1β)of(11.90±0.63)pg/ml,which were lower than(8.29±1.03)mg/L,(11.89±1.05)pg/ml,and(13.45±0.77)pg/ml in the control group(P<0.05).After treatment,the observation group had total cholesterol of(5.23±1.15)mmol/L,triglyceride of(2.21±0.19)mmol/L and low-density lipoprotein cholesterol of(2.75±0.33)mmol/L,which were lower than(6.78±1.60),(3.32±0.37)and(3.98±0.39)mmol/L in the control group(P<0.05).After treatment,the scores of disease,physiology,psychology,society and satisfaction in the observation group were(1.61±0.20),(2.15±0.29),(2.56±0.18),(2.02±0.13)and(1.73±0.11)points,which were lower than(3.57±0.28),(3.65±0.45),(3.67±0.12),(3.18±0.15)and(3.12±0.29)points in the control group(P<0.05).Conclusion Saxagliptin combined with metformin has a clear therapeutic effect on type 2 diabetes mellitus patients.It can improve the glucose metabolism and islet function of patients,regulate the level of blood lipids,inhibit the release of micro inflammatory factors,and is beneficial to the prognosis.It is worth popularizing.
SaxagliptinMetforminType 2 diabetes mellitusBlood glucose control rate
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