Study on value of combined detection of serum BNP,hs-CRP,UA and cTnT in the diagnosis of heart failure
Objective To analyze the value of combined detection of serum B-type natriuretic peptide(BNP),high-sensitivity C-reactive protein(hs-CRP),uric acid(UA)and cardiac troponin T(cTnT)in the diagnosis of heart failure(HF).Methods The data of 103 patients with HF were retrospectively analyzed,and they were taken as the study group;the data of 98 healthy subjects were retrospectively analyzed and taken as the control group.Both groups of subjects were tested for serum BNP,hs-CRP,UA and cTnT.Comparison was made on serum BNP,hs-CRP,UA and cTnT levels between the two groups,serum BNP,hs-CRP,UA and cTnT levels in HF patients with New York Heart Association(NYHA)classification of grade Ⅰ-Ⅱ and Ⅲ-Ⅳ,as well as the detection rate of serum BNP,hs-CRP,UA,and cTnT alone and in combination for HF.Results The serum BNP,hs-CRP,UA and cTnT in the study group were(290.95±45.68)pg/ml,(5.12±1.02)mg/L,(432.26±30.58)μmol/L and(17.03±3.52)pg/ml,which were higher than(47.56±15.00)pg/ml,(1.36±0.46)mg/L,(285.65±35.44)μmol/L and(6.45±2.02)pg/ml in the control group(P<0.05).The levels of serum BNP,hs-CRP,UA and cTnT in HF patients with NYHA classification of grade Ⅲ-Ⅳ were(336.52±50.66)pg/ml,(6.02±0.98)mg/L,(460.46±40.49)μmol/L and(19.56±3.00)pg/ml,which were higher than(236.65±45.88)pg/ml,(4.05±1.00)mg/L,(398.65±35.45)μmol/L and(14.02±3.02)pg/ml in HF patients with NYHA classification of gradeⅠ-Ⅱ(P<0.05).The detection rate of combined detection of four serum indicators for HF was 88.35%,which was higher than 72.82%,67.96%,60.19%,56.31%of BNP,hs-CRP,UA,cTnT alone(P<0.05).Conclusion The combined detection of serum BNP,hs-CRP,UA and cTnT levels can improve the diagnostic accuracy,and has clinical application value.
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