Objective To analyze the effect of clopidogrel combined with aspirin in the treatment of coronary heart disease in the elderly.Methods A total of 60 elderly patients with coronary heart disease were included and randomly divided into a study group and a conventional group,with 30 cases in each group.The study group received clopidogrel combined with aspirin treatment,while the conventional group received aspirin treatment.Both groups were compared in terms of treatment effects,inflammatory markers[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and hypersensitive C-reactive protein(hs-CRP)],coagulation function[prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(Fbg)],and adverse reactions.Results The total effective rate of 93.33%in the study group was significantly higher than 73.33%in the conventional group,and the difference was significant(P<0.05).Before treatment,there was no significant difference in IL-6,TNF-α and hs-CRP between the two groups(P>0.05).After treatment,the study group had IL-6 of(34.15±3.14)pg/ml,TNF-α of(103.23±18.40)pg/ml and hs-CRP of(7.53±1.35)mg/L,which were higher than(43.71±3.56)pg/ml,(137.88±20.41)pg/ml and(9.54±1.81)mg/L in the conventional group,and the difference was significant(P<0.05).Before treatment,there was no significant difference in APTT,PT and Fbg between the two groups(P>0.05).After treatment,the study group had APTT of(33.19±2.03)s,PT of(13.14±1.36)s and Fbg of(2.12±0.85)g/L,which were better than(30.89±3.11)s,(11.58±2.47)s and(3.11±1.02)g/L in the conventional group.The difference was significant(P<0.05).The incidence of adverse reactions in the study group was 10.00%,which was lower than 33.33%in the conventional group,and the difference was significant(P<0.05).Conclusion Clopidogrel combined with aspirin is effective in the treatment of elderly patients with coronary heart disease.
ClopidogrelAspirinCoronary heart disease in the elderlyClinical efficacy
NETL
NSTL
万方数据
