Clinical efficacy analysis of clopidogrel combined with aspirin in the treatment of coronary heart disease in the elderly
Objective To analyze the effect of clopidogrel combined with aspirin in the treatment of coronary heart disease in the elderly.Methods A total of 60 elderly patients with coronary heart disease were included and randomly divided into a study group and a conventional group,with 30 cases in each group.The study group received clopidogrel combined with aspirin treatment,while the conventional group received aspirin treatment.Both groups were compared in terms of treatment effects,inflammatory markers[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and hypersensitive C-reactive protein(hs-CRP)],coagulation function[prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(Fbg)],and adverse reactions.Results The total effective rate of 93.33%in the study group was significantly higher than 73.33%in the conventional group,and the difference was significant(P<0.05).Before treatment,there was no significant difference in IL-6,TNF-α and hs-CRP between the two groups(P>0.05).After treatment,the study group had IL-6 of(34.15±3.14)pg/ml,TNF-α of(103.23±18.40)pg/ml and hs-CRP of(7.53±1.35)mg/L,which were higher than(43.71±3.56)pg/ml,(137.88±20.41)pg/ml and(9.54±1.81)mg/L in the conventional group,and the difference was significant(P<0.05).Before treatment,there was no significant difference in APTT,PT and Fbg between the two groups(P>0.05).After treatment,the study group had APTT of(33.19±2.03)s,PT of(13.14±1.36)s and Fbg of(2.12±0.85)g/L,which were better than(30.89±3.11)s,(11.58±2.47)s and(3.11±1.02)g/L in the conventional group.The difference was significant(P<0.05).The incidence of adverse reactions in the study group was 10.00%,which was lower than 33.33%in the conventional group,and the difference was significant(P<0.05).Conclusion Clopidogrel combined with aspirin is effective in the treatment of elderly patients with coronary heart disease.
ClopidogrelAspirinCoronary heart disease in the elderlyClinical efficacy
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NSTL
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