Clinical observation of nifuratel tablet combined with ciprofloxacin hydrochloride suppository in the treatment of bacterial vaginitis
Objective To observe the effectiveness of nifuratel tablet combined with ciprofloxacin hydrochloride suppositorics in the treatment of bacterial vaginitis.Methods 100 patients with bacterial vaginitis were divided into hydrochloride treatment group and combined treatment group according to the order of treatment,with 50 cases in each group.The hydrochloride treatment group was treated with ciprofloxacin hydrochloride suppository,and the combined treatment group was treated with nifuratel tablets combined with ciprofloxacin hydrochloride suppository.The time required for symptom-based adjustment,inflammatory factors,serum oxidative stress index and the occurrence of adverse reactions were compared between the two groups.Results In the combined treatment group,the recovery time of leukorrhea was(5.41±1.26)d,the relief time of vaginal pruritus was(4.23±1.08)d,the relief time of mucosal congestion was(7.20±0.69)d,and the relief time of vaginal pain was(3.15±0.24)d,which were shorter than(8.26±1.20),(7.16±1.33),(10.57±0.48),and(6.11±0.42)d in the hydrochloride treatment group(P<0.05).After treatment,the combined treatment group had interleukin-2 of(4.12±0.52)ng/ml,interleukin-8 of(1.30±0.24)ng/ml,interleukin-13 of(10.22±1.68)ng/ml,while the hydrochloride treatment group had interleukin-2 of(7.94±0.12)ng/ml,interleukin-8 of(3.25±0.81)ng/ml,interleukin-13 of(21.44±0.46)ng/ml;the interleukin-2,interleukin-8 and interleukin-13 in the combined treatment group were lower than those in the hydrochloride treatment group(P<0.05).After treatment,the combined treatment group had malondialdehyde of(3.62±0.12)nmol/ml,serum endothelin-1 of(53.42±4.16)ng/L,superoxide dismutase of(95.64±8.88)U/ml,and serum nitric oxide of(102.36±8.65)μmol/ml;the hydrochloride treatment group had malondialdehyde of(4.81±0.05)nmol/ml,endothelin-1 of(64.23±8.15)ng/L,superoxide dismutase of(82.63±6.49)U/ml,and nitric oxide of(85.42±6.35)μmol/ml.The malondialdehyde and endothelin-1 in the combined treatment group were lower than those in the hydrochloride treatment group,and the superoxide dismutase and serum nitric oxide in the combined treatment group were higher than those in the hydrochloride treatment group(P<0.05).The incidence of adverse reactions in the combined treatment group was lower than that in the hydrochloride treatment group(P<0.05).Conclusion In the treatment of bacterial vaginitis,it is necessary to select the treatment mode of nifuratel tablet combined with ciprofloxacin hydrochloride suppository,which can better adjust the patient's adverse symptoms,reduce the inflammatory factor and serum stress response indexes and so on,and guarantee the safety of patient treatment,which can be vigorously promoted.
Nifuratel tabletCiprofloxacin hydrochloride suppositoryBacterial vaginitisPractical value
NETL
NSTL
万方数据
