Efficacy and safety of Xiangsha Pingwei granules in the treatment of digestive tract diseases:a systematic review and Meta-analysis
Objective To evaluate the efficacy and safety of Xiangsha Pingwei granules in the treatment of digestive tract diseases.Methods The CNKI,Wanfang,Weipu,PubMed and Embase databases were searched according to the relevant search terms.Review Manager 5.4 software was used to calculate pooled odd ratio(OR)or mean difference(MD)(95%CI),perform heterogeneity test,and assess publication bias.Results Totally 14 literatures were enrolled,with good quality and low risk of bias.Meta-analysis showed that the total effective rate of Xiangsha Pingwei granules combined with western medicine in treatment of digestive tract diseases was higher than that of western medicine alone[95%CI=(3.69,9.28),P<0.001],with no heterogeneity among studies(I2=0.0%,P=0.55).On the clinical symptom score,Xiangsha Pingwei granules combined with western medicine could significantly improve postprandial fullness,early satiation,epigastric pain and epigastric burning(P<0.05).On the level of gastrointestinal hormones,Xiangsha Pingwei granules could significantly improve the levels of motilin,gastrin and plasma substance P(P<0.001).Furthermore,Xiangsha Pingwei granules can effectively remove Helicobacter pylori(Hp)and did not increase adverse reactions.Conclusion Compared with conventional western medicine,Xiangsha Pingwei granule combined with western medicine can significantly improve total clinical effective rate,clinical symptom score and gastrointestinal hormone level,remove Hp,with less adverse reactions and high safety.
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