Clinical efficacy and safety evaluation of combination therapy with sacubitril-valsartan and atorvastatin in patients with coronary heart disease and heart failure
Objective To explore the clinical efficacy and safety of combination therapy with sacubitril-valsartan and atorvastatin in patients with coronary heart disease and heart failure.Methods A total of 120 patients with coronary heart disease and heart failure were randomly divided into an observation group and a control group,with 60 cases in each group.The observation group received the combined treatment of sacubitril-valsartan and atorvastatin,and the control group received the combined treatment of enalapril maleate and atorvastatin.The heart function grading after treatment,treatment effect,and systolic blood pressure(SBP)and diastolic blood pressure(DBP)before and after treatment,and occurrence of adverse reactions were compared between the two groups.Results The heart function grading of the observation group was better than that of the control group after treatment,but the difference was not statistically significant(P>0.05).The total effective rate of the observation group was 76.67%,which was significantly higher than 56.67%of the control group,and the difference was statistically significant(P<0.05).After treatment,SBP and DBP in the observation group were(116.25±16.35)and(79.58±8.36)mm Hg(1 mm Hg=0.133 kPa),which were significantly lower than(125.36±15.36)and(86.63±8.25)mm Hg in the control group.The difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of sacubitril-valsartan and statins in the treatment of patients with coronary heart disease and heart failure has good clinical effect and high safety,which can provide doctors with more accurate guidance to help them make appropriate treatment choices.
NETL
NSTL
万方数据
维普
