Investigation of the effect of dapagliflozin in the treatment of patients with heart failure
Objective To explore the effect of dapagliflozin in the treatment of heart failure.Methods 72 patients with heart failure were divided into a control group and an observation group by random number table method,with 36 cases in each group.The control group was treated with conventional treatment,and the observation group was treated with conventional treatment and dapagliflozin.Both groups were compared in terms of therapeutic effect,cardiac function indicators,inflammatory factors,B-type natriuretic peptide(BNP)level,6-min walking distance,occurrence of adverse reactions,and quality of life score.Results The total effective rate of the observation group was 94.44%,which was higher than 75.00%of the control group(P<0.05).Before treatment,there was no statistically significant difference in left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)and left ventricular end-systolic diameter(LVESD)between the two groups(P>0.05).After treatment,the observation group had LVEDD of(42.16±6.35)mm,LVEF of(47.28±6.14)%and LVESD of(29.63±6.67)mm,which were better than(46.53±5.51)mm,(43.69±5.68)%and(34.15±5.58)mm in the control group(P<0.05).Before treatment,there was no significant difference in C-reactive protein(CRP)and interleukin-6(IL-6)between the two groups(P>0.05).After treatment,the observation group had CRP of(4.29±0.57)mg/L and IL-6 of(11.24±1.05)ng/L,which were lower than(6.45±0.46)mg/L and(17.23±1.18)ng/L in the control group(P<0.05).Before treatment,the difference in BNP and 6-min walking distance between the observation group and the control group were small(P>0.05).After treatment,the observation group had BNP of(246.89±87.94)pg/ml and 6-min walking distance of(328.67±30.13)m,which were better than(285.43±75.46)pg/ml and(281.67±29.65)m in the control group(P<0.05).There was no significant difference in incidence of adverse reactions between the observation group and the control group(P>0.05).The scores of material life,psychological function,physical function and social function in the observation group were(74.18±7.72),(75.26±7.74),(73.24±8.26)and(67.53±7.15)points,which were higher than(69.65±8.13),(70.23±8.65),(66.35±7.13)and(61.68±6.24)points in the control group(P<0.05).Conclusion The application of dapagliflozin in the treatment of heart failure is effective,which can not only improve the cardiac function,inflammatory response and quality of life of patients,without increase of adverse reactions,which is worthy of clinical adoption and promotion.
NETL
NSTL
万方数据
维普
