Observation on clinical effect of Yangxue Shengfa decoction combined with compound betamethasone injection in the treatment of patients with alopecia areata
Objective To explore the clinical efficacy of Yangxue Shengfa decoction combined with compound betamethasone injection in the treatment of alopecia areata.Methods 100 patients with alopecia areata were divided into a control group and a treatment group according to the random numerical table,with 50 patients in each group.The control group was treated with compound betamethasone injection,while the treatment group was treated with Yangxue Shengfa decoction and compound betamethasone injection.The clinical efficacy,hair growth,hair loss area and site score,light hair-pulling test score,dermatology life quality index(DLQI)score,immune function,adverse reactions and recurrence rate were compared between the two groups.Results The total effective rate of the treatment group was 96.00%,which was higher than 84.00%of the control group(P<0.05).After treatment,the scores of hair regeneration in the hair loss area,new hair density,new hair thickness and new hair color in both groups were lower than those before treatment;the scores of hair regeneration in the hair loss area,new hair density,new hair thickness and new hair color in the treatment group were(1.54±0.32),(0.84±0.19),(0.87±0.20)and(0.72±0.13)points,which were lower than(2.28±0.40),(1.20±0.27),(1.28±0.23)and(1.09±0.20)points in the control group(P<0.05).After treatment,the hair loss area and site score,light hair-pulling test score and DLQI score in both groups were lower than those before treatment;the hair loss area and site score,light hair-pulling test score and DLQI score in the treatment group were(0.51±0.12),(0.51±0.10)and(3.48±0.72)points,which were lower than(0.84±0.16),(0.68±0.12)and(6.51±1.15)points in the control group(P<0.05).After treatment,CD4+ and CD8+ levels in both groups were lower than those before treatment;the treatment group had CD4+ of(39.71±5.03)%and CD8+ of(21.32±3.60)%,which were lower than(42.90±5.87)%and(23.01±3.84)%in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(χ2=1.042,P=0.307>0.05).After 3 months of follow-up,the recurrence rate in the treatment group was 2.00%(1/50),which was lower than 16.00%(8/50)in the control group(χ2=5.983,P=0.014<0.05).Conclusion The combination of Yangxue Shengfa decoction and compound betamethasone injection is safe and effective in the treatment of alopecia areata,which can promote hair growth,improve immune function,reduce recurrence,and accelerate the recovery process.
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维普
