Clinical effects of aripiprazole combined with modified electric convulsive therapy in the treatment of refractory schizophrenia
Objective To study the clinical effects of aripiprazole combined with modified electric convulsive therapy in the treatment of refractory schizophrenia.Methods 86 patients with refractory schizophrenia were divided into a test group and a control group according to randomized number table method,each with 43 cases.Both groups were treated with aripiprazole,and the test group was also treated with modified electric convulsive therapy.Both groups were compared in terms of treatment effects,symptom scores(positive symptoms,negative symptoms,and general psychopathological scores),serum neurotrophic factors[brain-derived neurotrophic factor(BDNF),nerve growth factor(NGF),neurotrophin-3(NT-3)],and serum inflammatory factors[interleukin-4(IL-4),interleukin-6(IL-6),interleukin-1β(IL-1β)],and the incidence of adverse reactions.Results The excellent rate of treatment of 69.77%in the test group was higher compared with 41.86%in the control group(P<0.05).After treatment,the scores of positive symptom,negative symptom,general psychopathology and total score in both groups were lower than those before treatment;the scores of positive symptom,negative symptom,general psychopathology and total score of the test group were(15.51±2.64),(13.62±2.88),(22.53±5.82)and(51.66±6.78)points,which were lower than(20.21±5.47),(18.69±4.75),(27.66±7.82)and(66.56±9.24)points in the control group(P<0.05).After treatment,the levels of BDNF,NGF and NT-3 in both groups were higher than those before treatment;the test group had BDNF of(14.05±2.56)μg/L,NGF of(46.77±9.21)μg/L and NT-3 of(170.82±22.61)pg/ml,which were higher than(11.18±1.97)μg/L,(38.69±8.41)μg/L and(151.63±20.74)pg/ml in the control group(P<0.05).After treatment,IL-4 level in both groups was higher than that before treatment,and IL-6 and IL-1β levels were lower than those before treatment;the test group had higher IL-4 of(11.35±3.58)pg/ml than(9.52±2.64)pg/ml in the control group;the test group had IL-6 of(30.31±3.64)pg/ml and IL-1β of(26.85±3.62)pg/ml,which were lower than(41.49±5.73)and(35.85±4.86)pg/ml in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of aripiprazole and modified electric convulsive therapy in the treatment of refractory schizophrenia can significantly improve the therapeutic efficacy of the patients,and has a good effect on adjusting the balance of inflammation and enhancing the neurotrophic nutrition while positively alleviating the symptoms,and has a good safety profile,which is worthy of research and promotion.
Refractory schizophreniaModified electric convulsive therapyAripiprazoleSerum neurotrophic factorSerum inflammatory factorAdverse reactions
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