Clinical efficacy of gamma globulin combined with imipenem cilastatin sodium for injection in the treatment of severe pneumonia in infants and young children
Objective To explore the clinical efficacy of gamma globulin combined with imipenem cilastatin sodium for injection in the treatment of severe pneumonia in infants and young children.Methods 68 infants and young children with severe pneumonia were divided into a control group and a study group using the random number table method,with 34 cases in each group.The control group was treated with imipenem cilastatin sodium for injection,and the study group was treated with imipenem cilastatin sodium for injection and gamma globulin.Both groups were compared in terms of clinical efficacy,incidence of adverse reactions,serum inflammatory factor indicators[C-reactive protein(CRP)and procalcitonin(PCT)],immune function indicators(CD3+ and CD4+/CD8+),symptom scores,lung function indicators[forced expiratory volume in one second(FEV1)and ratio of FEV1 to forced vital capacity(FEV1/FVC)],and arterial blood gas indicators[arterial partial pressure of oxygen(PaO2)and arterial partial pressure of carbon dioxide(PaCO2)].Results The total effective rate of 100.00%in the study group was higher than 85.29%in the control group(P<0.05).After treatment,the levels of CRP and PCT in both groups were lower than those before treatment;the study group had CRP of(5.89±1.06)mg/L and PCT of(0.46±0.15)ng/ml,which were lower than(7.02±1.27)mg/L and(0.69±0.23)ng/ml in the control group(P<0.05).After treatment,the scores of cough,sputum and fever in both groups were lower than those before treatment;the study group had cough score of(1.17±0.39)points,sputum score of(1.06±0.31)points and fever score of(1.16±0.40)points,which were lower than(1.58±0.43),(1.52±0.48)and(1.61±0.45)points in the control group(P<0.05).After treatment,FEV1,FEV1/FVC and PaO2 in both groups were higher than those before treatment,and PaCO2 was lower than that before treatment;the study group had higher FEV1,FEV1/FVC and PaO2 than those in the control group,and lower PaCO2 than that in the control group(P<0.05).After treatment,CD3+ and CD4+/CD8+ in both groups were higher than those before treatment;the study group had CD3+ of(41.92±2.43)%and CD4+/CD8+ of(1.89±0.34),which were higher than(38.05±2.18)%and(1.52±0.31)in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion When treating severe pneumonia in infants and young children,the combination of imipenem cilastatin sodium for injection and gamma globulin can more effectively control the patient's condition,improve their inflammatory response,immune function,lung function,and arterial blood gas status,and there is no increase in adverse reactions after the combination of medication,indicating good medication safety.
Infants and young childrenSevere pneumoniaImipenem cilastatin sodium for injectionGamma globulin
NETL
NSTL
万方数据
维普
