Cost effectiveness comparison of generic irbesartan hydrochlorothiazide tablets and original drugs in the treatment of mild to moderate essential hypertension
Objective To compare the cost effectiveness(C/E)comparison of generic irbesartan hydrochlorothiazide tablets(trade name:Beiyue)and original drugs(trade name:Ambonor)in the treatment of mild to moderate essential hypertension.Methods A total of 88 cases of patients with newly diagnosed mild to moderate hypertension were selected as the study subjects.The patients were divided into the generic group and the original group by random number table method,with 44 cases in each group.The generic group took generic irbesartan hydrochlorothiazide tablets for treatment,and the original group took original drugs for treatment.The treatment effect,blood pressure changes before and after treatment,occurrence of adverse reactions and treatment cost were compared between the two groups.Results The total effective rate of the generic group was 95.45%,and that of the original group was 97.73%,and there was no significant difference between the two groups(P>0.05).There was significant difference in systolic blood pressure and diastolic blood pressure between the two groups before and after treatment(P<0.05).After 4 and 8 weeks of treatment,the systolic blood pressure and diastolic blood pressure in both groups were significantly lower than those before treatment(P<0.05).There was no significant difference in systolic blood pressure and diastolic blood pressure between the two groups before and after treatment(P>0.05).The incidence of adverse drug reactions in the generic group was 9.09%,and that in the original group was 6.82%,and there was no significant difference between the two groups(P>0.05).The generic group had direct cost of(52.27±9.85)yuan and the average daily cost of(0.93±0.18)yuan,which were lower than(374.00±103.18)yuan and(6.68±1.84)yuan in the original group(P<0.05).The generic group had better C/E of 0.55 than 3.83 in the original group.Conclusion The overall efficacy and safety of generic irbesartan hydrochlorothiazide tablets is similar to that of the original drug in the treatment of mild to moderate hypertension,but the cost of the generic drug is lower,and it is more suitable for long-term use.
Essential hypertensionIrbesartan and hydrochlorothiazide tabletsGenericsBrand-name drugCost effectiveness
NETL
NSTL
万方数据
维普
