Clinical effect of budesonide and terbutaline combined with tiotropium bromide in the treatment of chronic obstructive pulmonary disease in the elderly
Objective To explore the clinical effect of budesonide and terbutaline combined with tiotropium bromide in the treatment of chronic obstructive pulmonary disease(COPD)in the elderly.Methods 94 elderly patients with COPD were randomly divided into a control group and an observation group,with 47 cases in each group.The control group was treated with budesonide and terbutaline,and the observation group was treated with tiotropium bromide based on the control group.The clinical efficacy,lung function indicators,inflammatory factors,blood gas analysis indicators and COPD assessment test(CAT)score were compared between the two groups.Results The total effective rate of the observation group was 95.74%,which was higher than 74.47%of the control group(P<0.05).After treatment,the forced expiratory volume in one second(FEV1),forced vital capacity(FVC),peak expiratory flow rate(PEF)and maximum voluntary volume(MVV)in the observation group were(2.46±0.45)L,(2.98±0.40)L,(3.79±0.53)L/s and(62.38±10.34)L,which were higher than(1.81±0.42)L,(2.71±0.37)L,(3.03±0.51)L/s and(58.13±9.19)L in the control group(P<0.05).After treatment,the procalcitonin(PCT),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)were(0.36±0.10)μg/L,(5.21±2.08)mg/L,(6.18±2.09)ng/L and(6.72±1.13)ng/L,which were all lower than(0.75±0.13)μg/L,(10.47±2.76)mg/L,(10.34±2.82)ng/L and(10.94±1.65)ng/L in the control group(P<0.05).After treatment,the arterial partial pressure of oxygen(PaO2)of the observation group was(80.67±6.15)mm Hg(1 mm Hg=0.133 kPa),which was higher than(71.43±5.78)mm Hg of the control group;the arterial partial pressure of carbon dioxide(PaCO2)and CAT score were(42.28±3.59)mm Hg and(15.12±4.06)points in observation group,which were lower than(54.81±4.12)mm Hg and(20.66±5.23)points in the control group(P<0.05).Conclusion Budesonide and terbutaline combined with tiotropium bromide has significant clinical effect in treating COPD in the elderly,which can effectively inhibit inflammatory reaction,dilate bronchi,improve lung function,promote the recovery of blood gas indexes and relieve the condition.
Chronic obstructive pulmonary diseaseBudesonideTerbutalineTiotropium bromideOld age
NETL
NSTL
万方数据
维普
