Efficacy and safety of ilaprazole combined with thrombin in the treatment of gastritis complicated with peptic ulcer bleeding
Objective To explore the efficacy and safety of ilaprazole combined with thrombin in the treatment of gastritis complicated with peptic ulcer bleeding.Methods 50 patients with gastritis complicated with peptic ulcer bleeding were divided into a control group and a study group by random number table method,with 25 cases in each group.The control group was treated with thrombin,and the study group was treated with ilaprazole sodium for injection on the basis of the control group.The efficacy,quality of life,levels of inflammatory factors and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the study group was 92.00%,which was significantly higher than 68.00%of the control group(P<0.05).After treatment,the scores of physiological function,psychological status,material life and social relationship in both groups were higher than those before treatment;the scores of physiological function,psychological status,material life and social relationship in the study group were(80.46±4.62),(82.81±3.89),(82.11±3.49),and(81.63±4.85)points,which were higher than(75.37±3.65),(75.18±2.83),(72.18±3.82),and(73.52±3.17)points in the control group(P<0.05).After treatment,the levels of C-reactive protein,interleukin-6 and interleukin-1 in both groups were lower than those before treatment;the study group had C-reactive protein of(3.35±0.79)mg/L,interleukin-6 of(40.63±5.24)ng/L,and interleukin-1 of(16.43±5.16)ng/L,which were lower than(5.59±0.57)mg/L,(62.37±3.53)ng/L,and(25.18±5.14)ng/L in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of ilaprazole combined with thrombin for patients with gastritis complicated with peptic ulcer bleeding can significantly improve the clinical effect,improve the serum inflammatory factors and quality of life of patients,reduce the incidence of adverse reactions,and have high safety,which is worthy of clinical promotion and application.
NETL
NSTL
万方数据
维普
