Effects of narrow-spectrum UVB combined with acitretin on inflammatory factors and immune function in patients with psoriasis vulgaris
Objective To explore the effects of narrow-spectrum UVB combined with acitretin on inflammatory factors and immune function in patients with psoriasis vulgaris.Methods 70 patients with psoriasis vulgaris were divided into a control group(35 cases)and an observation group(35 cases)according to random number table method.The control group was treated with narrow-spectrum UVB rays irradiation,and the observation group was treated with oral acitretin based on the control group.Both groups were compare in terms of clinical efficacy,occurrence of adverse reactions,the levels of T lymphocyte subsets(CD3+,CD4+,CD8+)and inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP)]before and after treatment.Results The total effective rate of the observation group was 94.29%(33/35),which was significantly higher than that of the control group 74.29%(26/35),P<0.05.Compared with observation group before treatment CD4+(30.06±4.21)%and the control group after treatment CD4+(34.38±3.47)%comparison,the observation group after treatment CD4+(39.39±3.60)%increased significantly(P<0.05);Compared with observation group before treatment CD8+(29.53±2.88)%and the control group after treatment of CD8+(26.50±2.48)%comparison,the observation group after treatment of CD8+(21.50±2.25)%significantly decreased(P<0.05).The TNF-α,IL-6 and CRP of the observation group after treatment(7.1±2.0)ng/ml,(111.6±20.5)pg/L,(4.4±2.0)mg/L were significantly lower than those before treatment(15.3±2.6)ng/ml,(179.3±25.8)pg/L,(9.8±2.8)mg/L and those of the control group after treatment(9.3±2.2)ng/ml,(138.6±21.2)pg/L,(6.7±2.3)mg/L(P<0.05).The incidence of adverse reactions of the observation group was 51.43%(18/35),which was not significantly different from that of the control group 42.86%(15/35)(χ2=0.516,P=0.473>0.05).Conclusion In the treatment of psoriasis vulgaris,narrow-spectrum UVB combined with acitretin can improve clinical efficacy,regulate T lymphocyte function imbalance,reduce inflammatory cytokines,and have high safety,which is worthy of promotion.
Psoriasis vulgarisAcitretinNarrow-spectrum UVBInflammatory factorsImmune function
NETL
NSTL
万方数据
维普
