Clinical study on intravenous thrombolysis for acute mild posterior circulation infarction
Objective To explore the clinical effect of intravenous thrombolysis for acute mild posterior circulation infarction.Methods 50 patients with acute mild posterior circulation infarction were divided into a control group(n=28 cases)and an observation group(n=22 cases)according to different thrombolytic methods.The control group received thrombolytic therapy with aspirin and clopidogrel,while the observation group received thrombolytic therapy with ateplase.Patients in both groups were compared in terms of National Institutes of Health Stroke Scale(NIHSS)score and expanded-NIHSS(e-NIHSS)score,coagulation function indicators[D-dimer,activated partial thromboplastin time(APTT),prothrombin time(PT)]before and after treatment,modified Rankin scale(mRS)score at 90 d after treatment,and recurrence.Results At 1 and 14 d after treatment,NIHSS and e-NIHSS scores in both groups were significantly lower than those before treatment(P＜0.05).At 14 d after treatment,the observation group had NIHSS score of(0.92±0.25)points and e-NIHSS score of(0.98±0.27)points,which were significantly lower than(1.53±0.31)and(1.57±0.33)points in the control group(P＜0.05).There were no significant differences in NIHSS and e-NIHSS scores between the two groups before treatment and 1 d after treatment(P＞0.05).At 14 d after treatment,the observation group had D-dimer of(0.71±0.27)mg/L,APTT of(36.23±3.36)s,PT of(15.49±1.34)s,which were significantly better than(1.17±0.35)mg/L,(22.48±3.27)s,(10.31±1.44)s in the control group(P＜0.05).The observation group had mRS score of(1.12±0.54)points at 90 d after treatment,which was significantly lower than(1.91±0.63)points in the control group(P＜0.05).The recurrence rate of the observation group was 0,which was significantly lower than 17.86%of the control group(P＜0.05).Conclusion In the intravenous thrombolysis treatment of acute mild posterior circulation infarction,alteplase can achieve comprehensive effects in terms of disease control and curative effect,and has significant advantages in improving prognosis and reducing recurrence rate,which is worthy of promotion and application.
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万方数据
维普
