Study on clinical effect of levofloxacin combined with ambroxol in the treatment of elderly patients with chronic obstructive pulmonary disease complicated with lung infection
Objective Exploring the effect of combining levofloxacin with ambroxol in elderly patients with chronic obstructive pulmonary disease(COPD)complicated with pulmonary infection.Methods 106 elderly COPD patients with pulmonary infection were selected and randomly divided into an observation group and a control group,with 53 cases in each group.The control group received treatment with levofloxacin,while the observation group received additional treatment with ambroxol.Compare the clinical efficacy,incidence of adverse reactions,and inflammatory cytokine indicators[C-reactive protein(CRP),procalcitonin(PCT)],lung function indicators[forced expiratory volume at 1 second(FEV1),forced vital capacity(FVC)],oxidative stress indicators[superoxide dismutase(SOD),malondialdehyde(MDA)]between two groups of patients before and after treatment.Results The total effective rate of 94.34%in the observation group was higher than 81.13%in the control group(P＜0.05).After treatment,the FEV1(2.70±0.13)L and FVC(3.40±0.39)L in the observation group were higher than those in the control group(2.63±0.11)and(3.23±0.42)L(P＜0.05).After treatment,the serum CRP(14.20±1.12)mg/L and PCT(0.86±0.15)ng/ml in the observation group were lower than those in the control group(15.13±1.57)mg/L and(0.92±0.14)ng/ml(P＜0.05);the observation group had higher SOD of(95.86±6.09)U/L than(84.91±5.65)U/L in the control group,and lower MDA of(5.45±1.59)μmol/L than(6.29±1.48)μmol/L in the control group(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Elderly patients with chronic obstructive pulmonary disease complicated with lung infection should be treated with a combination of levofloxacin and ambroxol regimen,which helps to improve the lung function of the patients and alleviate the inflammatory response and oxidative stress of the patients'organisms,and its safety is also worthy of affirmation,which is of good value for popularization and application.
LevofloxacinAmbroxolChronic obstructive pulmonary disease in the elderlyLung infectionClinical value
NETL
NSTL
万方数据
维普
