Study on the efficacy of methylprednisolone combined with montelukast sodium in the treatment of recurrent Henoch-Schonlein purpura in children
Objective To analyze the effect of methylprednisolone combined with montelukast sodium in the treatment of recurrent Henoch-Schonlein purpura(HSP)in children.Methods 60 children with recurrent HSP were divided into a control group and a study group using random number table,with 30 cases in each group.The control group was treated with montelukast sodium,and the study group was combined with methylprednisolone sodium succinate based on the control group.Patients in both groups were compared in terms of clinical efficacy,symptom improvement time,occurrence of adverse reactions,recurrence,and immunoglobulin indexes[immunoglobulin(Ig)M,IgA],inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP),procalcitonin(PCT),tumor necrosis factor-α(TNF-α)]before and after treatment.Results The total effective rate of the study group(96.67%)was higher than that of the control group(73.33%),and the difference was statistically significant(P＜0.05).In the study group,the relief time of gastrointestinal symptoms,joint symptoms and skin purpura were(3.62±0.56),(3.80±0.70)and(7.22±1.02)d;in the control group,the relief time of gastrointestinal symptoms,joint symptoms and skin purpura were(5.02±0.50),(5.22±0.75)and(9.20±1.56)d.Compared with the control group,the relief time of gastrointestinal symptoms,joint symptoms and skin purpura in the study group was shorter,and the difference was statistically significant(P＜0.05).After treatment,IgM and IgA levels in the study group were(1.55±0.25)and(5.20±0.85)g/L,while those in the control group were(2.10±0.34)and(7.35±1.02)g/L.Compared with the control group,the study group showed lower levels of IgM and IgA,and the difference was statistically significant(P＜0.05).After treatment,the levels of IL-6,CRP,PCT and TNF-α in the study group were(4.30±0.40)μg/L,(4.32±1.20)mg/L,(0.32±0.13)ng/ml and(3.23±1.00)ng/L,and those in the control group were(4.80±0.30)μg/L,(5.75±1.80)mg/L,(0.47±0.15)ng/ml and(5.75±1.20)ng/L.Compared with the control group,the study group showed lower levels of IL-6,CRP,PCT and TNF-α,and the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).After 6 months of follow-up,the recurrence rate of the study group was 6.67%,which was lower than 30.00%of the control group,and the difference was statistically significant(P＜0.05).Conclusion The combination of methylprednisolone and montelukast sodium is effective in treating recurrent HSP in children.It can effectively promote symptom recovery,regulate immunoglobulin levels,inhibit inflammatory reactions,and reduce the recurrence rate.
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万方数据
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