Analysis of therapeutic effect of invasive mechanical ventilation on ICU patients with severe heart failure
Objective To analyze the effect of invasive mechanical ventilation on intensive care unit(ICU)patients with severe heart failure.Methods 68 ICU patients with severe heart failure were selected and randomly divided into a study group and a control group,with 34 cases in each group.The control group received with oxygen inhalation through a high-flow nasal catheter on the basis of conventional treatment,while the study group received invasive mechanical ventilation on the basis of conventional treatment.Both groups were compared in terms of blood gas indexes[arterial partial pressure of oxygen(PaO2),percutaneous arterial oxygen saturation(SpO2),arterial partial pressure of carbon dioxide(PaCO2)],hemodynamic indexes[extravascular lung water index(EVLWI),global end-diastolic volume index(GEDVI)and cardiac function index(CFI)],markers of myocardial injury[N-terminal pro-brain natriuretic peptide(NT-proBNP)and cardiac troponin T(cTnT),and clinical efficacy.Results There were no significant differences in baseline PaO2,SpO2 and PaCO2 between the study group and the control group(P＞0.05).At 48 h after treatment,PaO2 and SpO2 of the study group were significantly higher than those of the control group(P＜0.05).There was no statistical difference in PaCO2 between the two groups(P＞0.05).There was no statistical difference in baseline EVLWI,GEDVI and CFI between the two groups(P＞0.05).At 48 h after treatment,EVLWI,GEDVI and CFI of the two groups were significantly different from baseline,and EVLWI of the study group was lower than that of the control group,while GEDVI and CFI of the control group were higher(P＜0.05).There was no significant difference between baseline serum NT-proBNP and cTnT between the two groups(P＞0.05).At 48 h after treatment,the study group had NT-proBNP of(1521.6±851.4)pg/ml and cTnT of(0.9±0.4)μg/L,which were significantly lower than(2041.2±912.9)pg/ml and(1.8±0.7)μg/L in the control group(P＜0.05).The total effective rate of the study group was 97.1%,which was significantly higher than 76.5%of the control group(P＜0.05).Conclusion Invasive mechanical ventilation in ICU patients with severe heart failure can improve the therapeutic effect,promote the improvement of blood gas and hemodynamics,and reduce myocardial damage.
Intensive care unitHeart failureInvasive mechanical ventilation
NETL
NSTL
万方数据
维普
