Evaluation of diagnostic value of biochemical indexes in patients with liver disease
Objective To explore the value of biochemical indexes in the diagnosis of patients with liver disease.Methods 100 patients with liver disease were selected as the study group,and 100 healthy volunteers were selected as the control group.Peripheral venous blood was collected from both groups in the early morning fasting state,centrifuged and processed,and then serum was taken to test the biochemical indexes[aspartate transaminase(AST),alanine aminotrasferase(ALT),alkaline phosphatase(ALP),total bile acids(TBA),total bilirubin(TBIL)].The biochemical indexes of the study group and the control group were compared.The biochemical indexes of patients with viral hepatitis and cirrhosis were compared.Patients with liver cirrhosis were taken as positive cases and patients with viral hepatitis as negative cases.The differential diagnostic efficacy of single and combined detection of biochemical index for different types of liver disease was compared.Results The study group had serum AST of(46.97±8.05)U/L,ALT of(47.15±9.28)U/L,ALP of(128.14±15.24)U/L,TBA of(12.87±3.12)μmol/L,and TBIL of(20.90±4.19)μmol/L,which were higher than(24.53±4.68)U/L,(26.10±4.91)U/L,(84.37±10.46)U/L,(5.46±1.70)μmol/L,and(12.81±3.37)μmol/L in the control group(P＜0.05).Patients with liver cirrhosis had serum AST of(50.62±4.73)U/L,ALT of(51.89±5.64)U/L,ALP of(141.48±8.35)U/L,TBA of(14.68±2.29)μmol/L,and TBIL of(24.07±3.82)μmol/L,which were higher than(45.33±4.29)U/L,(45.02±5.13)U/L,(122.15±7.67)U/L,(12.06±1.85)μmol/L,and(19.48±3.04)μmol/L in patients with viral hepatitis(P＜0.05).The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of combined detection were higher than those of AST,ALT,ALP,TBA and TBIL detection alone(P＜0.05).There was no significant difference in sensitivity,specificity,accuracy,positive predictive value and negative predictive value of AST,ALT,ALP,TBA and TBIL detection alone(P＞0.05).Conclusion The level of biochemical indexes in patients with liver disease is abnormally increased,which can accurately detect liver disease and accurately differentiate the different types of liver disease,and has good diagnostic value.
NETL
NSTL
万方数据
维普
