Study on clinical value of glycated hemoglobin combined with hematocrit and thyroid function indicators in the diagnosis of gestational diabetes mellitus
Objective To explore the value of glycated hemoglobin(HbA1c)combined with hematocrit(HCT)and thyroid function indicators[serum free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH)]in the diagnosis of gestational diabetes mellitus(GDM).Methods The clinical data of 200 pregnant women who were screened for early GDM were retrospectively analyzed.All pregnant women were examined by HbA1c,HCT,thyroid function index at 12-16 weeks of gestation and oral glucose tolerance test(OGTT)during the second trimester of pregnancy.The results of different examination methods were compared,the HbA1c,HCT and thyroid function indexes of normal and abnormal mid-trimester OGTT pregnant women were compared,and the sensitivity and specificity of HbA1c,HCT and thyroid function indicators in the diagnosis of GDM at 12-16 weeks of gestation were analyzed.Results HbA1c,HCT and thyroid function indicators were examined in 200 pregnant women at 12-16 weeks of gestation,192 cases were normal,the normal rate was 96.0%,8 cases were abnormal,the abnormal rate was 4.0%;by mid-trimester OGTT,183 cases were normal,the normal rate was 91.5%,17 cases were abnormal,the abnormal rate was 8.5%;there was no significant difference in abnormal rates between HbA1c,HCT and thyroid function indicators at 12-16 weeks of gestation and mid-trimester OGTT(P＞0.05).The levels of HbA1c,HCT and TSH in pregnant women with abnormal mid-trimester OGTT were(9.07±0.61)%,(40.41±3.23)%and(4.01±0.85)mlU/L,which were obviously higher than(4.69±0.35)%,(37.72±2.98)%and(1.95±0.78)mlU/L in pregnant women with normal mid-trimester OGTT;the FT3 and FT4 in pregnant women with abnormal mid-trimester OGTT were(3.68±0.54)pmol/L and(10.22±1.59)pmol/L,which were significantly lower than(4.52±0.73)and(14.01±1.76)pmol/L in pregnant women with normal mid-trimester OGTT.The difference was statistically significant(P＜0.05).The sensitivity and specificity of HbA1c,HCT and thyroid function indicators for GDM were 41.2%and 99.5%,using results of mid-trimester OGTT as the gold standard.Conclusion HbA1c combined with HCT and thyroid function indicators have high specificity for early diagnosis of GDM,and can be used as diagnostic indicators for GDM patients.
NETL
NSTL
万方数据
维普
