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蒙脱石散结合双歧杆菌三联活菌胶囊治疗小儿腹泻的效果及安全性分析

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目的 分析腹泻患儿行蒙脱石散联合双歧杆菌三联活菌胶囊治疗的效果。方法 94 例腹泻患儿,根据随机法将患儿分为对照组和观察组,每组 47 例。对照组利用蒙脱石散治疗,观察组则在对照组基础上结合双歧杆菌三联活菌胶囊治疗。对比两组临床疗效、症状改善时间、免疫功能[免疫球蛋白G(IgG)、免疫球蛋白A(IgA)]及不良反应发生情况。结果 观察组总有效率 95。74%相比对照组的82。98%更高,差异具有统计学意义(P<0。05)。观察组治疗后呕吐改善时间、腹痛缓解时间、大便恢复正常时间、发热消退时间分别为(1。15±0。34)、(1。26±0。23)、(2。28±0。87)、(1。12±0。23)d,相较于对照组的(2。69±0。65)、(2。73±0。51)、(4。47±1。13)、(2。54±0。76)d更短,差异具有统计学意义(P<0。05)。两组治疗前的IgG、IgA比较,差异无统计学意义(P>0。05);观察组治疗后IgG(13。78±2。43)g/L、IgA(1。96±0。43)g/L比对照组的(10。97±1。87)、(1。32±0。19)g/L高,差异具有统计学意义(P<0。05)。观察组不良反应发生率和对照组比较无差异(P>0。05)。结论 腹泻患儿应用蒙脱石散和双歧杆菌三联活菌胶囊共同治疗能够明显提升疗效,可促使其临床症状快速消除,有效改善患儿免疫功能,减少不良反应发生情况,临床上值得推广使用。
Efficacy and safety analysis of montmorillonite powder combined with bifidobacterium triple viable capsules in the treatment of infantile diarrhea
Objective To analyze the effect of montmorillonite powder combined with bifidobacterium triple viable capsules in the treatment of infantile diarrhea.Methods 94 cases of infantile diarrhea were randomly divided into a control group and an observation group,with 47 cases in each group.The control group was treated with montmorillonite powder,and the observation group was treated with bifidobacterium triple viable capsules based on the control group.The clinical efficacy,symptom improvement time,immune function[immunoglobulin G(IgG),immunoglobulin A(IgA)],and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of 95.74%in the observation group was higher than 82.98%in the control group,and the difference was statistically significant(P<0.05).After treatment,the improvement time of vomiting,relief time of abdominal pain,recovery time of stool and remission time of fever in the observation group were(1.15±0.34),(1.26±0.23),(2.28±0.87)and(1.12±0.23)d,which were shorter than(2.69±0.65),(2.73±0.51),(4.47±1.13)and(2.54±0.76)d in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in IgG and IgA between the two groups(P>0.05).After treatment,the observation group had IgG of(13.78±2.43)g/L and IgA of(1.96±0.43)g/L,which were higher than(10.97±1.87)and(1.32±0.19)g/L in the control group,and the difference was statistically significant(P<0.05).There was no difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion The combined treatment of montmorillonite powder and bifidobacterium triple viable capsules in children with diarrhea can significantly improve the efficacy,promote the rapid elimination of clinical symptoms,effectively improve the immune function of children,and reduce the occurrence of adverse reactions,which is worthy of clinical promotion and use.

Montmorillonite powderBifidobacterium triple viable capsulesInfantile diarrhea

付晓华

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276100 郯城县第一人民医院儿科

蒙脱石散 双歧杆菌三联活菌胶囊 小儿腹泻

2024

中国现代药物应用
中国水利电力医学科学技术学会

中国现代药物应用

影响因子:0.862
ISSN:1673-9523
年,卷(期):2024.18(8)
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