Clinical efficacy of self-made traditional Chinese medicine formula combined with azithromycin sequential therapy in children with mycoplasma pneumonia
Objective To observe the clinical efficacy of self-made traditional Chinese medicine formula combined with azithromycin sequential therapy in children with mycoplasma pneumonia.Methods 60 child patients with mycoplasma pneumonia were divided into a control group and a study group using a random number table method,with 30 cases in each group.The control group was treated with azithromycin sequential therapy,while the study group was treated with self-made traditional Chinese medicine formula based on the control group.Comparison was made on the levels of serum inflammatory markers[C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6)]before and after treatment,improvement time and disappearance time of cough and sputum,fever,moist rale and wheezing rale,therapeutic effect,and occurrence of adverse reactions between two groups of children.Results In the study group,the levels of CRP,PCT,and IL-6 before treatment were(30.96±2.76)mg/L,(2.95±0.27)ng/ml,and(69.75±1.52)pg/ml,respectively.After treatment,the levels of CRP,PCT,and IL-6 were(13.86±2.22)mg/L,(0.69±0.11)ng/ml,and(24.49±1.45)pg/ml,respectively.In the control group,the levels of CRP,PCT,and IL-6 before treatment were(30.71±2.88)mg/L,(2.83±0.24)ng/ml,and(70.01±1.47)pg/ml,respectively.After treatment,the levels of CRP,PCT,and IL-6 were(17.17±3.55)mg/L,(0.98±0.18)ng/ml,and(37.18±2.31)pg/ml,respectively.After treatment,CRP,PCT,and IL-6 levels decreased in both groups compared with those before treatment,with a greater decrease in the study group(P＜0.05).In the study group,the time of significant improvement of cough and sputum,fever,moist rale and wheezing rale were(2.25±0.25),(1.88±0.57),(2.53±0.27)and(2.88±0.57)d;the disappearance time were(3.14±0.23),(2.75±0.52),(5.65±0.97)and(5.35±0.79)d.In the control group,the significant improvement time of cough,sputum production,fever,moist rale and wheezing rale were(3.34±0.45),(2.65±0.66),(3.96±0.18)and(4.24±0.93)d;the disappearance time were(4.76±0.61),(4.08±0.76),(6.91±1.16)and(6.94±1.53)d.The improvement time and disappearance time of cough,sputum production,fever,moist rale and wheezing rale in the study group were shorter than those in the control group(P＜0.05).The total effective rate of the study group was 93.33%,which was higher than 70.00%of the control group;the incidence of adverse reactions of the study group was 3.33%,which was lower than 26.67%of the control group(P＜0.05).Conclusion Compared to continuous treatment of azithromycin,sequential treatment can better control the condition and shorten the course of the disease.It is more ideal to use self-made traditional Chinese medicine formula in combination to shorten the course of the disease and reduce the occurrence of adverse reactions.
Self-made traditional Chinese medicine formulaAzithromycinSequential therapyMycoplasma pneumonia in childrenSerum inflammatory markers
NETL
NSTL
万方数据
维普
