Clinical efficacy of methylprednisolone combined with doxofylline in the treatment of chronic obstructive pulmonary emphysema in the elderly
Objective To analyze the clinical efficacy of methylprednisolone combined with doxofylline in the treatment of chronic obstructive pulmonary emphysema in the elderly.Methods A total of 114 elderly patients with chronic obstructive pulmonary emphysema were divided into an observation group and a control group by envelope drawing method,with 57 cases in each group.The control group was treated with antibiotics,and the observation group was treated with methylprednisolone combined with doxofylline.Patients in both groups were compared in terms of inflammatory factors[interleukin-8(IL-8),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],blood gas index[arterial oxygen saturation(SaO2),arterial partial pressure of carbon dioxide(PaCO2),arterial partial pressure of oxygen(PaO2)]and pulmonary function index[ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC),peak expiratory flow(PEF),FEV1]levels,clinical effects,and occurrence of adverse reactions.Results After treatment,the levels of IL-8,IL-6 and TNF-α decreased significantly in both groups;the observation group had IL-8 of(20.65±3.38)pg/ml,IL-6 of(23.47±6.15)ng/L and TNF-α of(123.41±17.64)pg/ml,which were significantly lower than(34.35±5.17)pg/ml,(42.55±7.11)ng/L and(155.75±20.47)pg/ml in the control group;there was a statistical difference(P<0.05).After treatment,the levels of SaO2,PaCO2 and PaO2 were significantly improved in both groups;the observation group had SaO2 of(96.34±4.90)%and PaO2 of(79.45±5.64)mm Hg(1 mm Hg=0.133 kPa),which were higher than(89.22±3.87)%and(73.28±4.55)mm Hg in the control group;the observation group had lower PaCO2 of(40.34±3.23)mm Hg than(53.67±4.27)mm Hg in the control group;there was a statistical difference(P<0.05).After treatment,the levels of FEV1/FVC,PEF and FEV1 were significantly increased in both groups;the observation group had FEV1/FVC of(75.76±9.31)%,PEF of(4.66±0.96)L/s and FEV1 of(4.42±0.82)L,which were significantly higher than(66.94±8.08)%,(3.70±0.74)L/s and(3.38±0.52)L in the control group;there was a significant difference(P<0.05).The total effective rate of the observation group was 94.74%,which was significantly higher than 82.46%of the control group,and there was a statistical difference(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of methylprednisolone and doxofylline in the treatment of elderly patients with chronic obstructive pulmonary emphysema can help patients improve lung function,blood gas indicators,reduce inflammation in the body,and promote overall treatment effectiveness.
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