Analysis of the current status of antiplatelet drug resistance and its influencing factors in ischemic stroke patients in eastern Fengxian
Objective To analyze the occurrence and influencing factors of antiplatelet drug resistance in ischemic stroke patients in eastern Fengxian,so as to provide reference for individual clinical treatment.Methods A total of 282 patients with ischemic stroke who were hospitalized in the Department of Neurology of Fengcheng Hospital and treated with aspirin,clopidogrel or a combination of the two were selected.The maximum aggregation rate(MAR)after admission was detected.Clinical data of patients were collected;the occurrence of antiplatelet drug resistance was analyzed.The influencing factors of platelet drug resistance were analyzed.Results Among 282 patients,61 cases were treated with aspirin alone,23 cases were treated with clopidogrel alone,and 198 cases were treated with aspirin plus clopidogrel.The incidence of aspirin resistance(AR)was 37.5%(97/259),and the incidence of clopidogrel resistance(CR)was 46.6%(103/221).The proportion of AR patients with combined diabetes was 35.1%,which was higher than 22.8%of non-aspirin resistant(NAR)patients(P<0.05).There were no significant differences between AR patients and NAR patients in terms of age,gender,hypertension,coronary heart disease,smoking history,platelet count,mean platelet volume,platelet volume distribution width,platelet-large cell ratio(P-LCR),low density lipoprotein cholesterol,total cholesterol,glycated hemoglobin,homocysteine,and fibrinogen(P>0.05).The female proportion of CR patients was 49.5%,which was higher than 35.6%of non-clopidogrel resistant(NCR)patients(P<0.05).There was no significant difference between CR patients and NCR patients in terms of age,hypertension,diabetes,coronary heart disease,smoking history,platelet count,mean platelet volume,platelet volume distribution width,platelet-large cell ratio,low density lipoprotein cholesterol,total cholesterol,glycated hemoglobin,homocysteine,and fibrinogen(P>0.05).Logistic regression analysis showed that diabetes was an independent risk factor for AR(P<0.05).Conclusion The ischemic stroke patients in eastern Fengxian are mainly elderly patients over 65 years old.The resistance rate of antiplatelet drugs is relatively high,and the CR rate is higher than that of AR rate.Female are more likely to develop CR than male;combined diabetes may be an independent high risk factor for AR in ischemic stroke patients.In clinical work,elderly patients with ischemic stroke should be actively controlled of their blood pressure and blood sugar and be paid attention to the presence of AR and CR for individualized treatment.
万方数据
维普
