Diagnostic value of tumor markers in benign and malignant pleural effusion
Objective To explore the diagnostic value of tumor markers in benign and malignant pleural effusion.Methods 52 patients with pleural effusion were divided into lung cancer experimental group(malignant,26 cases)and benign control group(benign,26 cases)according to clinical diagnosis.Pleural effusion and venous blood of patients were respectively extracted synchronously.Tumor markers[carcinoembryonic antigen(CEA),glycoprotein antigen 125(CA125),cytokeratin 19 fragment(Cyfra21-1)and neuron-specific enolase(NSE)]levels were simultaneously detected by electrochemiluminescence immunoassay.The levels of tumor markers in pleural effusion and serum were compared between the two groups,and the sensitivity,specificity and accuracy of the combined and single detection of tumor markers were compared.Results In benign control group,the levels of CEA,CA125,Cyfra21-1 and NSE in pleural effusion were(2.99±1.25)ng/ml,(25.55±9.52)U/ml,(2.86±2.77)ng/ml and(8.75±8.24)ng/ml;the serum CEA,CA125,Cyfra21-1 and NSE levels were(1.88±2.35)ng/ml,(23.15±5.93)U/ml,(1.75±2.05)ng/ml and(5.85±5.43)ng/ml.In lung cancer experimental group,the levels of CEA,CA125,Cyfra21-1 and NSE in pleural effusion were(121.24±127.35)ng/ml,(351.11±249.81)U/ml,(35.99±41.26)ng/ml,and(105.27±110.85)ng/ml;the serum CEA,CA125,Cyfra21-1 and NSE levels were(41.33±64.36)ng/ml,(189.48±105.85)U/ml,(26.46±31.23)ng/ml and(17.18±21.26)ng/ml.The levels of CEA,CA125,Cyfra21-1 and NSE in pleural effusion and serum of lung cancer experimental group were significantly higher than those of benign control group(P<0.05).The levels of CEA,CA125,Cyfra21-1 and NSE in pleural effusion of lung cancer experimental group were significantly higher than the levels of tumor markers in serum(P<0.05).The sensitivity,specificity and accuracy of combined detection of CEA+CA125+Cyfra21-1+NSE were higher than those of single detection of CEA,CA125,Cyfra21-1 and NSE(P<0.05).Conclusion The combined detection of CEA,CA125,Cyfra21-1 and NSE tumor markers in the serum and pleural effusion of patients with pleural effusion has high sensitivity,specificity and accuracy,which can be applied to the diagnosis of benign and malignant pleural effusion in clinical practice,improve the accuracy of clinical diagnosis and provide reference for clinical treatment.
Benign and malignant pleural effusionTumor markersJoint detectionDiagnostic value
万方数据
维普
