Clinical significance of detection of human amyloid β-peptide 1-42 and phosphorylated tau protein 181 in serum of patients with Alzheimer's disease
Objective To explore the clinical significance of detection of human amyloid β-peptide 1-42(Aβ1-42)and phosphorylated tau protein 181(p-tau-181)in serum of patients with Alzheimer's disease(AD).Methods 60 AD patients were served as the AD group,and were divided into the mild AD group(20 cases)and the moderate and above AD group(40 cases)based on the different scores of the Mini-Mental Status Examination(MMSE)score;75 healthy subjects who underwent a physical examination at the same time were selected as the healthy control group.Serum Aβ1-42 and p-tau-181 levels were measured in both groups.Comparison was made on serum Aβ1-42 and p-tau-18 levels of different genders between AD group and healthy control group,serum Aβ1-42 and p-tau-18 levels between AD group and healthy control group,and serum Aβ1-42 and p-tau-18 levels of patients with different severity in the AD group.Results There were no significant differences in serum Aβ1-42 and P-TAU-18 levels between male and female subjects in healthy control group(P>0.05).There were no significant differences in serum Aβ1-42 and P-taU-18 levels between male and female patients in AD group(P>0.05).The serum levels of Aβ1-42 and P-taU-18 in AD group were(102.0±12.3)and(22.1±6.9)pg/ml,which were significantly higher than(33.7±10.6)and(10.9±7.1)pg/ml in healthy control group,and the difference was statistically significant(P<0.05).Serum levels of Aβ1-42 and p-taU-18 in moderate and above AD group were(108.2±11.1)and(25.3±7.3)pg/ml,which were higher than(89.6±9.8)and(15.7±8.6)pg/ml in mild AD group,and the difference was statistically significant(P<0.05).Conclusion Serum Aβ1-42 and p-tau-181 are highly expressed in AD patients,and their concentrations are positively correlated with severity of condition of AD patients.
Alzheimer's diseaseHuman amyloid β-peptide 1-42Phosphorylated tau protein 181
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