Clinical effect analysis of atorvastatin in the treatment of progressive stroke
Objective To explore the clinical effect of atorvastatin in the treatment of progressive stroke.Methods 96 patients with progressive stroke were randomly divided into a control group and an observation group,with 48 cases in each group.The control group was treated with routine therapy,and the observation group was treated with atorvastatin.The clinical efficacy,National Institute Health Stroke scale(NIHSS)score,Barthel index(BI),blood lipid index and hemorheology index were compared.Results The total effective rate of the observation group was 95.83%,which was significantly higher than 77.08%of the control group(P<0.05).After treatment,the observation group had lower NIHSS score of(10.15±2.87)points than(14.27±3.62)points in the control group,and higher BI score of(73.51±8.35)points than(60.94±9.27)points in the control group(P<0.05).After treatment,the observation group had total cholesterol(TC)of(4.45±0.61)mmol/L,triglycerides(TG)of(1.31±0.22)mmol/L,and low-density lipoprotein cholesterol(LDL-C)of(2.78±0.35)mmol/L,which were lower than(5.22±0.68),(1.57±0.25),and(3.68±0.47)mmol/L in the control group;while the observation group had higher high-density lipoprotein cholesterol(HDL-C)of(1.32±0.20)mmol/L than(1.04±0.21)mmol/L in the control group(P<0.05).After treatment,the observation group had plasma viscosity of(1.40±0.29)mPa·s,hematocrit of(36.89±3.37)%,whole blood high shear viscosity of(4.70±1.03)mPa·s,and whole blood low shear viscosity of(9.78±2.25)mPa·s,which were lower than(1.76±0.31)mPa·s,(44.68±4.09)%,(5.26±1.09)mPa·s,and(11.32±2.40)mPa·s in the control group(P<0.05).Conclusion Atorvastatin has a significant clinical effect on progressive stroke,which can effectively reduce blood lipid and blood viscosity,promote the repair of damaged neurological function and improve the ability of daily living.
万方数据
维普
