Clinical efficacy of metoprolol combined with irbesartan in the treatment of hypertension in the elderly
Objective To explore the clinical effect of metoprolol combined with irbesartan in the treatment of hypertension in the elderly.Methods 120 elderly patients with hypertension were randomly divided into a dual antihypertensive group and a single antihypertensive group,with 60 patients in each group.The single antihypertensive group was treated with irbesartan,and the dual antihypertensive group was treated with metoprolol on the basis of the single antihypertensive group.The blood pressure level,blood pressure compliance rate,quality of life score and incidence of adverse reactions were compared between the two groups.Results After 1,2 and 3 months of treatment,the systolic blood pressure of the dual antihypertensive group were(140.03±14.25),(135.71±15.72),(133.24±12.02)mm Hg(1 mm Hg=0.133 kPa),and the diastolic blood pressure were(86.25±5.37),(84.69±4.52),(82.36±5.62)mm Hg,which were significantly lower than(150.71±13.85),(145.02±14.13),(138.52±14.78)mm Hg and(91.39±6.87),(87.25±5.37),(85.19±4.98)mm Hg in the single antihypertensive group(P<0.05).After 1,2 and 3 months of treatment,the blood pressure compliance rate of the dual antihypertensive group were 63.33%,76.67%and 93.33%,which were significantly higher than 41.67%,58.33%and 78.33%of the single antihypertensive group(P<0.05).After treatment,the scores of physical function,role-emotional,physical function,social function,mental health,energy and total score in 36-item short-form health survey(SF-36)in the dual antihypertensive group were significantly higher than those in the single antihypertensive group(P<0.05).There was no significant difference in the incidence of adverse reactions between the dual antihypertensive group and the single antihypertensive group[11.67%(7/60)vs 8.33%(5/60)](P>0.05).Conclusion Combined treatment with metoprolol on the basis of irbesartan antihypertensive therapy can effectively reduce the blood pressure level in elderly patients with hypertension,improve the blood pressure compliance rate,quality of life,and it has high safety and good prognosis.
万方数据
维普
