Comparison of antihypertensive effect between compound reserpine and irbesartan and hydrochlorothiazide
Objective To compare the antihypertensive effect between compound reserpine and irbesartan and hydrochlorothiazide.Methods A total of 78 hypertensive patients were selected as research subjects.According to the random number table method,the patients were divided into a control group and a study group,with 39 cases in each group.The control group was treated with irbesartan and hydrochlorothiazide tablets,and the study group was treated with compound reserpine tablets.The treatment effect,occurrence of adverse reactions,and blood pressure before and after treatment of the two groups were compared.Results The total effective rate of the study group was 94.87%,and that of the control group was 79.49%;the study group was higher than the control group,and the difference was statistically significant(χ2=4.129,P<0.05).There was no statistical significance in the comparison of diastolic blood pressure and systolic blood pressure between the two groups before treatment(P>0.05).After treatment,the diastolic blood pressure and systolic blood pressure of the two groups were significantly lower than those before treatment;the study group had diastolic blood pressure of(78.39±5.17)mm Hg(1 mm Hg=0.133 kPa)and systolic blood pressure of(115.72±7.15)mm Hg,which were lower than(82.36±4.97)and(124.48±6.85)mm Hg in the control group;the differences were statistically significant(P<0.05).The incidence of adverse reactions in the study group(12.82%)was lower than that in the control group(17.95%),but there was no statistical significance between groups(χ2=0.394,P>0.05).Conclusion Compared with irbesartan and hydrochlorothiazide tablets,compound reserpine tablets have better antihypertensive effect and fewer adverse reactions,so it is recommended.
HypertensionCompound reserpine tabletsIrbesartan and hydrochlorothiazide tabletsEffect
万方数据
维普
