Study on efficacy of high-dose ambroxol combined with azithromycin on children with mycoplasma pneumoniae pneumonia and its influence on serum amyloid A level
Objective To observe the effect of high-dose ambroxol combined with azithromycin in the treatment of mycoplasma pneumoniae pneumonia in children,in order to ensure the overall benefit level of children.Methods 120 children with mycoplasma pneumoniae pneumonia were divided into a control group and an observation group by random number table method,with 60 cases in each group.The control group was treated with conventional dose of ambroxol hydrochloride injection and azithromycin granules,and the observation group was treated with high-dose ambroxol hydrochloride injection and azithromycin granules.Both groups were compared in terms of the treatment effect,the occurrence of adverse reactions and the lung function indicators[forced vital capacity(FVC),forced expiratory volume in one second(FEV1),peak expiratory flow rate(PEF)]at the end of treatment,blood gas analysis index[arterial partial pressure of oxygen(PaO2)and arterial partial pressure of carbon dioxide(PaCO2)],and serum amyloid A(SAA)level.Results The total effective rate of the observation group was 98.33%,which was higher than 86.67%of the control group,and the difference was statistically significant(P<0.05).At the end of treatment,FEV1,FVC and PEF in the control group were(1.08±0.49)L,(1.39±0.59)L and(1.81±0.60)L/s,and those in the observation group were(1.66±0.56)L,(1.81±0.62)L and(2.42±0.72)L/s.At the end of treatment,FEV1,FVC and PEF in both groups were higher than those before treatment,and the increase amplitude in the observation group was higher than that in the control group;the difference was statistically significant(P<0.05).At the end of treatment,the levels of PaO2,PaCO2 and SAA in the control group were(64.02±5.85)mm Hg(1 mm Hg=0.133 kPa),(55.65±4.15)mm Hg and(9.35±2.15)mg/L,and those in the observation group were(76.12±6.52)mm Hg,(41.85±3.65)mm Hg and(7.05±1.85)mg/L.At the end of treatment,PaO2 in both groups was higher than that before treatment,PaCO2 and SAA levels were lower than those before treatment;the increase amplitude of PaO2 and the decrease amplitude of PaCO2 and SAA levels in the observation group were higher than those in the control group;the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion High-dose ambroxol combined with azithromycin can significantly improve the therapeutic effect of children with mycoplasma pneumoniae pneumonia,help to improve blood gas analysis indexes,SAA levels,and improve lung function in children.It is safe and reliable,and is recommended to be promoted in clinical treatment.
ChildrenMycoplasma pneumoniae pneumoniaAmbroxol hydrochloride injectionHigh doseAzithromycin granulesSerum amyloid protein A
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