Analysis of the effect of azithromycin in the treatment of pediatric pneumonia
Objective To analyze the effect of azithromycin in the treatment of pediatric pneumonia.Methods 120 children with pneumonia were selected as the study subjects,and the above children were randomly divided into a control group and an experimental group,with 60 cases in each group.The control group was treated with erythromycin,and the experimental group was treated with azithromycin.The clinical efficacy,inflammatory factors[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6)],pulmonary function indicators[peak expiratory flow rate(PEF),forced expiratory volume in one second(FEV1),ratio of FEV1 to forced vital capacity(FEV1/FVC)]and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the experimental group was 96.67%,which was higher than the control group's 86.67%(P<0.05).After treatment,the experimental group had TNF-α of(1.31±0.28)ng/ml,CRP of(7.09±1.22)mg/L,and IL-6 of(62.25±5.18)pg/ml,which were lower than(2.26±0.30)ng/ml,(9.24±1.50)mg/L,and(100.85±7.34)pg/ml in the control group(P<0.05).After treatment,the experimental group had PEF of(4.05±0.58)L/s,FEV1 of(3.00±0.82)L,and FEV1/FVC of(80.55±5.38)%,which were higher than(3.56±0.49)L/s,(2.05±0.46)L,and(73.85±4.14)%in the control group(P<0.05).The incidence of adverse reactions in the experimental group was 5.00%,which was lower than the control group's 16.67%(P<0.05).Conclusion The application of azithromycin can effectively alleviate the clinical symptoms of children with pneumonia,improve their lung function,reduce the level of inflammatory factors,and play a very important role in improving the therapeutic effect of children and reducing the incidence of adverse reactions.
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