Clinical effect analysis of dexamethasone combined with different doses of gamma globulin in the treatment of children with severe immune thrombocytopenic purpura
Objective To explore the clinical effect of dexamethasone combined with different doses of gamma globulin in the treatment of children with severe immune thrombocytopenic purpura(ITP).Methods A total of 104 children with severe ITP were selected and divided into a control group(52 cases)and an observation group(52 cases)by simple randomization method.The control group was treated with dexamethasone combined with low-dose(400 mg)gamma globulin,and the observation group was treated with dexamethasone combined with high-dose(800 mg)gamma globulin.The clinical efficacy,length of hospital stay,platelet count and incidence of adverse reactions were compared between the two groups.Results The total clinical effective rate of the observation group(98.1%)was higher than that of the control group(86.5%)(P<0.05).The observation group had shorter length of hospital stay of(6.35±0.67)d than(11.23±1.15)d in the control group(P<0.05).Compared with before treatment,the platelet count of the two groups was significantly increased after 5 d of treatment(P<0.05).The observation group had higher platelet count of(158.39±12.05)×109/L after 5 d of treatment than(101.67±11.31)×109/L in the control group(P<0.05).The incidence of adverse drug reactions in the observation group(1.9%)was lower than that in the control group(13.5%)(P<0.05).Conclusion The combination of dexamethasone and different doses of gamma globulin can improve clinical symptoms in children with severe ITP;the efficacy of high-dose gamma globulin is better,the children's platelet count increases significantly,and the length of hospital stay is significantly shortened,and the safety of the children is better,which is more worthwhile to be promoted in the clinic.
Severe immune thrombocytopenic purpuraDexamethasoneGamma globulinClinical efficacy
万方数据
维普
