Effect of intravenous drip combined with atomization inhalation of ambroxol in the treatment of neonatal pneumonia
Objective To evaluate the effect of intravenous drip combined with atomization inhalation of ambroxol in the treatment of neonatal pneumonia.Methods A total of 72 neonates with pneumonia were studied and randomly divided into an intravenous drip group(n=36)and a combination group(n=36).The intravenous drip group was given intravenous drip of ambroxol on the basis of conventional treatment,and the combination group was given atomization inhalation of ambroxol on the basis of the control group.Both groups were compared in terms of time to symptom and sign resolution,length of hospital stay,blood gas indexes[arterial partial pressure of oxygen(PaO2)and arterial partial pressure of carbon dioxide(PaCO2)]and inflammation indexes[serum C-reactive protein(CRP)and interleukin-6(IL-6)]before treatment and 3 d after treatment,and the clinical efficacy.Results The duration of fever,shortness of breath,cough,pulmonary rales and length of hospital stay in the combination group were(3.1±1.3),(3.5±1.5),(5.2±1.7),(5.8±2.0)and(8.8±2.7)d,which were shorter than(3.9±1.5),(4.5±1.8),(6.3±2.3),(7.1±2.6)and(10.6±3.1)d in the intravenous drip group(P<0.05).3 d after treatment,the combination group had higher PaO2 of(76.0±9.1)mm Hg(1 mm Hg=0.133 kPa)than(70.1±8.7)mm Hg in the intravenous drip group;the combination group had PaCO2 of(45.1±4.3)mm Hg,serum CRP of(19.4±8.6)mg/L,and IL-6 of(141.6±51.7)ng/L,which were significantly lower than(47.7±5.5)mm Hg,(26.6±10.5)mg/L and(188.4±65.2)ng/L in intravenous drip group(P<0.05).There was no significant difference in the total effective rate between the two groups(χ2=1.059,P=0.303>0.05),but the effective rate of 83.3%in the combination group was higher than 61.1%in the intravenous drip group(χ2=4.431,P=0.035<0.05).Conclusion When using ambroxol to treat neonatal pneumonia,intravenous drip combined with atomization inhalation is a more ideal medication method.
万方数据
维普
